AB3637
Anti-DEDAF Antibody
Chemicon®, from rabbit
Synonyme(s) :
Anti-AAP1, Anti-APAP-1, Anti-DEDAF, Anti-YEAF1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Nom du produit
Anti-DEDAF Antibody, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, rat, mouse
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... RYBP(23429)
Application
Domaine de recherche
Apoptose et cancer
Apoptose et cancer
Sous-domaine de recherche
Apoptose - Autre
Apoptose - Autre
This Anti-DEDAF Antibody is validated for use in WB for the detection of DEDAF.
Western blotting : μ
A549 or HepG2 cell lysate can be used as a positive control and a 32 kDa band should be detected.
Il revient à l'utilisateur final de déterminer les dilutions de travail optimales.
A549 or HepG2 cell lysate can be used as a positive control and a 32 kDa band should be detected.
Il revient à l'utilisateur final de déterminer les dilutions de travail optimales.
Biochem/physiol Actions
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. DEDAF (DED Associated Factor) is expressed in multiple tissues and cell lines. DEDAF is identical to the transcriptional repressor RYBP. DEDAF interacts with FADD and augments the formation of CD95/FADD/Caspase-8 complexes at the cell membrane. DEDAF also interacts with DEDD (DED-containing DNA binding) protein in the nucleus, which indicates its involvement in the regulation of both cytoplasmic and nuclear events of apoptosis.
Disclaimer
Sauf indication contraire dans notre catalogue ou toute autre documentation associée au(x) produit(s), nos produits sont uniquement destinés à la recherche et ne sauraient être utilisés à d'autres fins, ce qui inclut, sans s'y limiter, les utilisations commerciales non autorisées, les utilisations diagnostiques in vitro, les utilisations thérapeutiques ex vivo ou in vivo, ou tout type de consommation ou d'application chez l'être humain ou chez l'animal.
Immunogen
Rabbit anti-DEDAF polyclonal antibody was raised against a synthetic peptide corresponding to amino acids 215 to 228 of human-DEDAF. This sequence is identical to the mouse sequence.
Physical form
Format : Produit purifié
Purified IgG by immunoaffinity chromatography. En solution dans du PBS contenant 0,02 % d'azoture de sodium.
Preparation Note
Conserver au réfrigérateur entre 2 et 8 °C pendant 12 mois maximum en aliquotes non diluées.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Classe de stockage
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Izabella Bajusz et al.
Genes, 10(11) (2019-11-23)
Separation of germline cells from somatic lineages is one of the earliest decisions of embryogenesis. Genes expressed in germline cells include apoptotic and meiotic factors, which are not transcribed in the soma normally, but a number of testis-specific genes are
Rybp/DEDAF is required for early postimplantation and for central nervous system development.
Pirity, MK; Locker, J; Schreiber-Agus, N
Molecular and cellular biology null
Paula Dobrinić et al.
Nature structural & molecular biology, 28(10), 811-824 (2021-10-06)
The Polycomb repressive system plays a fundamental role in controlling gene expression during mammalian development. To achieve this, Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) bind target genes and use histone modification-dependent feedback mechanisms to form Polycomb chromatin
Nathan R Rose et al.
eLife, 5 (2016-10-06)
Polycomb group (PcG) proteins function as chromatin-based transcriptional repressors that are essential for normal gene regulation during development. However, how these systems function to achieve transcriptional regulation remains very poorly understood. Here, we discover that the histone H2AK119 E3 ubiquitin
Dynamic antagonism between key repressive pathways maintains the placental epigenome.
Weigert, et al.
Nature Cell Biology, 25, 579-591 (2023)
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| AB3637 | 04053252583643 |
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