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Merck

AB4350

Anti-PRDM14 Antibody

from rabbit, purified by affinity chromatography

Synonyme(s) :

PR domain zinc finger protein 14, PR domain-containing protein 14

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A propos de cet article

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Species reactivity:
rat, mouse, human
Citations:
3
Technique(s):
western blot: suitable
Uniprot accession no.:
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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, mouse, human

technique(s)

western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

Gene Information

human ... PRDM14(63978)

Analysis Note

Evaluated by Western Blot in human lung tissue lysate.

Western Blot Analysis: A 1:1000 dilution of this antibody detected PRDM14 in 10 µg of human lung tissue lysate.

Application

This Anti-PRDM14 Antibody is validated for use in WB for the detection of PRDM14.

Biochem/physiol Actions

This antibody recognizes the N-terminus of PRDM14.

General description

PR domain proteins (PRDMs) have been associated with many types of human cancers. PRDM14 was found to be up-regulated in breast cancer cells. The expression of PRDM14 to breast cancer cells actually increased cell proliferation and decreased the effect of chemotherapeutic drugs, while down-regulation of PRDM14 did the opposite. In addition to breast cancer, PRDM14 has recently been linked to non-small cell lung cancer development. PRDM14 also seems to play a role in the preservation of the self-renewal of human embryonic stem cells and transcriptional regulation.
~62 kDa observed

Immunogen

GST-tagged recombinant protein corresponding to the N-terminus of human PRDM14.

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Classe de stockage

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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SOX17 is a critical specifier of human primordial germ cell fate.
Irie, N; Weinberger, L; Tang, WW; Kobayashi, T; Viukov, S; Manor, YS; Dietmann, S; Hanna et al.
Cell null
Yu Kang et al.
Cell reports, 25(9), 2563-2576 (2018-11-30)
Monkeys are an optimal model species for developing stem cell therapies. We previously reported generating chimeric cynomolgus monkey fetuses using dome-shaped embryonic stem cells (dESCs). However, conventional primed pluripotent stem cells (pPSCs) lack chimera competency. Here, by altering the media
Pengyi Yang et al.
Cell systems, 8(5), 427-445 (2019-05-13)
Pluripotency is highly dynamic and progresses through a continuum of pluripotent stem cell states. The two states that bookend the pluripotency continuum, naive and primed, are well characterized, but our understanding of the intermediate states and transitions between them remains

Numéro d'article de commerce international

RéférenceGTIN
AB435004053252421747

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