AB5038
Anti-α-Synuclein (SNCA) Antibody
CHEMICON®, rabbit polyclonal
Synonyme(s) :
alpha-synuclein, Alpha-synuclein
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A propos de cet article
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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Laissez-nous vous aiderNom du produit
Anti-Synuclein α Antibody, serum, Chemicon®
biological source
rabbit
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat, human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SNCA(6622)
Analysis Note
Control
Human brain sections.
Human brain sections.
Evaluated by Western Blot on Human Brain lysates.
Western Blot Analysis:
1:1000 dilution of this antibody detected Synuclein on 10 µg of human brain lysates.
Western Blot Analysis:
1:1000 dilution of this antibody detected Synuclein on 10 µg of human brain lysates.
Application
Anti-Synuclein Antibody, α detects level of Synuclein & has been published & validated for use in IC, IH, IH(P) & WB.
Immunohistochemistry:
1:1,000-1:2,000 dilutoin of a previous lot was used on paraffin sections; 1:4,000-1:12,000 dilution of a previous lot was used on frozen sections.
Western blot:
1:1,000-1:2,000. Shows a 14-19kDa band.
Immunocytochemistry:
Previous lot used IC.
Optimal working dilutions must be determined by end user.
1:1,000-1:2,000 dilutoin of a previous lot was used on paraffin sections; 1:4,000-1:12,000 dilution of a previous lot was used on frozen sections.
Western blot:
1:1,000-1:2,000. Shows a 14-19kDa band.
Immunocytochemistry:
Previous lot used IC.
Optimal working dilutions must be determined by end user.
Biochem/physiol Actions
Alpha-synuclein. The immunizing peptide was chosen to reduce cross-reactivity of AB5038 with β-synuclein to a minimum. Immunohistochemical and Western blot analysis of human brain indicates a high level of specificity.
Has not been tested on other species.
General description
alpha-Synuclein is a small (140 amino acid) cytoplasmic protein of unclear function that is enriched in presynaptic terminals and is the precursor protein of a nonamyloid beta component of senile plaques in Alzeheimer′s Disease (AD). α-Synuclein is located predominantly in the presynaptic nerve terminals in the brain but is also found in low concentrations in all tissues except liver. Recent studies have shown that abnormal aggregation and accumulation of synaptic proteins, including α-Synuclein might be associated with plaque formation in AD and seems to be a major component of Lewy bodies in dementia with Lewy bodies (DLB). It has also been identified in the Glial Cytoplasmic Inclusions (GCIs) found in Multiple System Atrophy (MSA).
~14-19 kDa
Immunogen
Epitope: a.a. 111-131
Human alpha-synuclein residue 111-131 coupled to KLH.
Other Notes
Replaces: 04-1053
Physical form
Rabbit polyclonal serum lyophilized, no preservatives. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any residue.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Classe de stockage
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Chiara Maria Giulia De Luca et al.
Translational neurodegeneration, 8, 24-24 (2019-08-14)
Parkinson's disease (PD) is a neurodegenerative disorder whose diagnosis is often challenging because symptoms may overlap with neurodegenerative parkinsonisms. PD is characterized by intraneuronal accumulation of abnormal α-synuclein in brainstem while neurodegenerative parkinsonisms might be associated with accumulation of either
Mitochondrial quality, dynamics and functional capacity in Parkinson's disease cybrid cell lines selected for Lewy body expression.
Cronin-Furman, EN; Borland, MK; Bergquist, KE; Bennett, JP; Trimmer, PA
Mol. Neurodegener. null
Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death.
Sugeno, N; Takeda, A; Hasegawa, T; Kobayashi, M; Kikuchi, A; Mori, F; Wakabayashi, K; Itoyama, Y
The Journal of Biological Chemistry null
TDP-43 pathology in the basal forebrain and hypothalamus of patients with amyotrophic lateral sclerosis.
Cykowski, MD; Takei, H; Schulz, PE; Appel, SH; Powell, SZ
Acta Neuropathologica Communications null
Dora Games et al.
The American journal of pathology, 182(3), 940-953 (2013-01-15)
Progressive accumulation of α-synuclein (α-syn) in limbic and striatonigral systems is associated with the neurodegenerative processes in dementia with Lewy bodies (DLB) and Parkinson's disease (PD). The murine Thy-1 (mThy1)-α-syn transgenic (tg) model recapitulates aspects of degenerative processes associated with
Contenu apparenté
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| AB5038 | 08436037126314 |
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