AG723-M
C-Reactive Protein
Synonyme(s) :
CRP
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A propos de cet article
UNSPSC Code:
12352202
NACRES:
NA.41
eCl@ss:
32160405
Form:
liquid
Assay:
>98% (SDS-PAGE)
Biological source:
human
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Laissez-nous vous aiderbiological source
human
assay
>98% (SDS-PAGE)
form
liquid
manufacturer/tradename
Chemicon®
NCBI accession no.
UniProt accession no.
General description
C-reactive protein (CRP) is a homopentameric acute-phase inflammatory protein, which belongs to the pentraxin family. It is a highly conserved plasma protein produced mainly in liver hepatocytes. It is also synthesized by lymphocytes, smooth muscle cells, macrophages, endothelial cells, and adipocytes.
Application
C-reactive protein (CRP) has been used:
- as a model analyte for interference-reduced detection of CRP in serum using non-competitive sandwich immunoassay in combination with surface plasmon field-enhanced fluorescence spectroscopy (SPFS)
- to determine the involvement of collectin placenta 1 (CL-P1) in CRP-mediated complement activation and to investigate the downstream effects of this complement activation
- to examine to study the effects of lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) on CRP-induced complement activation by interacting with CRP to develop an inflammatory pathogenic response
Biochem/physiol Actions
C-reactive protein (CRP) plays a vital role in the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release. It also regulates the production of interleukin-6 and tumor necrosis factor-α. Patients suffering from appendicitis, cholecystitis, pancreatitis, and meningitis have elevated levels of CRP. CRP facilitates the uptake of low-density lipoprotein in macrophages. It has a crucial role in the pathophysiology of cardiovascular disease, which makes it a useful marker for inflammation and cardiovascular events.
Physical form
Liquid in 100mM NaCl, 10mM Tris-HCl with 0.1% sodium azide, 2mM CaCl2
Preparation Note
Maintain under sterile conditions at 2-8°C for up to one year. Do not freeze. Full safety precautions should be taken as in the handling of any potentially infective body fluid.
Analysis Note
No precipitin bands when tested at 2 mg/mL against anti-whole human serum.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Classe de stockage
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Nitai Roy et al.
Biochimica et biophysica acta, 1860(6), 1118-1128 (2016-03-01)
C-reactive protein (CRP) is a plasma pentraxin family protein that is massively induced as part of the innate immune response to infection and tissue injury. CRP and other pentraxin proteins can activate a complement pathway through C1q, collectins, or on
Development of a cluster of differentiation antibody-based protein microarray.
Michael Abdo, Bob Irving, Peter Hudson, Heddy Zola
Journal of Immunological Methods null
Yoshiko Fujita et al.
Clinical chemistry, 56(3), 478-481 (2010-01-16)
C-reactive protein (CRP) increases in response to inflammation and is purported to be a risk factor for atherogenesis. We recently demonstrated that a scavenger receptor, lectin-like oxidized LDL receptor (LOX-1), is a receptor for CRP. In light of the overlapping
Lectin-like Oxidized LDL Receptor 1 Is Involved in CRP-Mediated Complement Activation.
Fujita Y, Yamaguchi S, Kakino A, Iwamoto S, Yoshimoto R, Sawamura T.
Clinical Chemistry null
Safaa I Khater et al.
Biomedicines, 10(7) (2022-07-28)
Oxidative stress is considered the main etiologic factor involved in inflammatory bowel disease (IBD). Integration of nanocarriers for natural therapeutic agents with antioxidant and anti-inflammatory potential is a novel promising candidate for curing IBD. Herein, the colonic antioxidant and anti-inflammatory
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| AG723 | 04053252507243 |
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