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Merck

HSP3MAG-63K

MILLIPLEX® Human Sepsis Panel

Configurable Human Sepsis 5-Plex Panel 3

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A propos de cet article

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

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Nom du produit

MILLIPLEX® Human Sepsis Panel,

species reactivity

human

Quality Level

200

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

assay range

accuracy: 82%
(Lactoferrin), accuracy: 98%
(Lipocalin-2/NGAL), standard curve range: 10-10,000 pg/mL
(Resistin), standard curve range: 195-200,000 pg/mL
(Lactoferrin and Thrombospondin-1 (TSP1)), standard curve range: 20-20,000 pg/mL
(Neutrophil Elastase-2 (ELA2)), standard curve range: 29-30,000 pg/mL
(Lipocalcin-2/NGAL)

technique(s)

multiplexing: suitable

input

cell culture supernatant
serum

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

description

Configurable Human Sepsis 5-Plex Panel 3

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Catégories apparentées

General description

Sepsis or SIRS (systemic inflammatory response syndrome) results from infection, whether bacterial, viral, fungal, or parasitic. The pathogenesis of sepsis is very complex. Both an innate and acquired immune response to infection interrupts homeostasis with a shift of cytokine expression that increases immunosuppression. In addition, migration of the leukocytes in the inflamed tissues secretes a tissue factor leading to the formation of thrombin, also triggering the release of chemokines and adhesion molecules through endothelial cells. Severe sepsis occurs when hypotension or hypoperfusion to one or more organs leads to organ dysfunction, which, in turn, can cause septic shock, multiple organ dysfunction syndrome (MODS) and death.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 5 analytes in human serum, plasma, and cell culture supernatants.

Analytes included: Lactotransferrin, Lipocalin-2/NGAL, Neutrophil Elastase-2 (ELA2), Resistin, Thrombospondin-1 (TSP-1)

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

  • Comprehensive Sepsis Biomarker Coverage: Luminex® xMAP® platform simultaneously quantitates 5 critical sepsis biomarkers (Lactotransferrin, Neutrophil Elastase-2, NGAL/Lipocalin-2, Resistin, Thrombospondin-1) targeting key pathways in sepsis pathogenesis and organ dysfunction.
  • Complete Assay Solution: Ready-to-use 96-well format includes lyophilized standard cocktail and two internal quality controls, enabling analysis of up to 38 samples in duplicate with comprehensive quality assurance.
  • Optimized Sample Processing: Compatible with human serum, plasma, and cell/tissue culture supernatants using 1:100 dilution for serum/plasma samples, maximizing sample conservation while maintaining analytical sensitivity.
  • Sepsis Research Applications: Investigate biomarkers involved in sepsis progression from SIRS to severe sepsis and septic shock, supporting research into immune dysfunction, organ failure mechanisms, and experimental therapeutic interventions.
  • Multi-Pathway Research Analysis: Simultaneously measure neutrophil activation, acute kidney injury markers, antimicrobial responses, metabolic dysfunction indicators, and vascular integrity markers for comprehensive sepsis research.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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Atqah AbdulWahab et al.
Cureus, 13(6), e15948-e15948 (2021-07-06)
Background and purpose Neutrophil elastase (NE) has been implicated in the pathogenesis of airway inflammation in cystic fibrosis (CF) patients and it impairs defenses against Pseudomonas aeruginosa (PA) infection or colonization. Sputum NE may act as a biomarker of neutrophilic inflammation in CF
Seungwon An et al.
The ocular surface, 17(3), 589-614 (2019-04-10)
To investigate the role of neutrophil extracellular traps (NETs) and NET-associated proteins in the pathogenesis of oGVHD and whether dismantling of NETs with heparin reduces those changes. Ocular surface washings from oGVHD patients and healthy subjects were analyzed. Isolated peripheral

Numéro d'article de commerce international

RéférenceGTIN
HSP3MAG-63K-0204053252803383
HSP3MAG-63K-0304053252803390
HSP3MAG-63K-0504053252803413
HSP3MAG-63K-0404053252803406
HSP3MAG-63K-0104053252803376

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