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Merck

MAB1676

Anti-Talin 1 Antibody, NT, a.a. 139-433, clone TA205

clone TA205, Chemicon®, from mouse

Synonyme(s) :

Anti-ILWEQ, Anti-TLN, Anti-talin-1

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A propos de cet article

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
TA205, monoclonal
Application:
IHC, IP, WB
Citations:
20

Principaux documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

TA205, monoclonal

species reactivity

rabbit, human

should not react with

mouse, rat

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG1

NCBI accession no.

NM_006289.2

UniProt accession no.

Q9Y490

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... TLN1(7094)

Immunogen

Epitope: N-terminus, a.a. 139-433

Application

Anti-Talin 1 Antibody, N-terminus, a.a. 139-433, clone TA205 detects level of Talin & has been published & validated for use in IP, WB, IH.
Immunoblotting, recognizes a band at ~230kDa.

Immunoprecipitation

Immunofluorescence

Optimal working dilutions must be determined by end user.

Biochem/physiol Actions

Human Talin. This antibody reacts with an N-terminal epitope in talin, between amino acids 139-433. On microinjection into whole cells MAB1676 disrupts actin stress fibers and focal contacts and inhibits cell motility.

Physical form

Format: Purified
Liquid in 0.02 M PB pH 7.6, 0.25 M NaCl containing 0.1% sodium azide.

Preparation Note

Maintain between 2 and 8°C for up to six months.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Classe de stockage

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Daniel Friedman et al.
Journal of cell science, 134(7) (2021-03-14)
Natural killer (NK) cells can kill infected or transformed cells via a lytic immune synapse. Diseased cells may exhibit altered mechanical properties but how this impacts NK cell responsiveness is unknown. We report that human NK cells were stimulated more
Masaru Niki et al.
Thrombosis and haemostasis, 115(5), 969-978 (2016-01-23)
Adaptor proteins play a critical role in the assembly of signalling complexes after engagement of platelet receptors by agonists such as collagen, ADP and thrombin. Recently, using proteomics, the Dok (downstream of tyrosine kinase) adapter proteins were identified in human
Karen P Fong et al.
Cellular microbiology, 8(11), 1753-1767 (2006-07-11)
Actinobacillus actinomycetemcomitans produces a leukotoxin (Ltx) that kills leukocyte function-associated antigen-1 (LFA-1)-bearing cells from man, the Great Apes and Old World monkeys. The unique specificity of Ltx for the beta2 integrin, LFA-1, suggests it is capable of providing insight into
Karen P Fong et al.
Blood advances, 5(23), 4901-4909 (2021-09-28)
Blood clot contraction is driven by traction forces generated by the platelet cytoskeleton that are transmitted to fibrin fibers via the integrin αIIbβ3. Here we show that clot contraction is impaired by inhibitors of the platelet cytosolic protease calpain. We
Haizhi Wang et al.
Biochemistry, 54(18), 2806-2816 (2015-04-25)
Alzheimer's disease (AD) is characterized by the deposition of amyloid β (Aβ), a peptide generated from proteolytic processing of its precursor, amyloid precursor protein (APP). Canonical APP proteolysis occurs via α-, β-, and γ-secretases. APP is also actively degraded by
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Numéro d'article de commerce international

RéférenceGTIN
MAB167604053252317071

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