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Merck

85886

Streptomycin solution

~1 mg/mL in 1 mM EDTA, analytical standard

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A propos de cet article

Formule empirique (notation de Hill) :
C21H39N7O12 · 1.5H2SO4
Numéro CAS:
3810-74-0
Poids moléculaire :
728.69
NACRES:
NA.24
PubChem Substance ID:
329769423
UNSPSC Code:
41116107
MDL number:
MFCD00037023

Principaux documents

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InChI

1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1

SMILES string

OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N

InChI key

QTENRWWVYAAPBI-YZTFXSNBSA-N

grade

analytical standard

form

liquid

concentration

~1 mg/mL in 1 mM EDTA

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

color

colorless

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria

application(s)

pharmaceutical (small molecule)

format

single component solution

mode of action

protein synthesis | interferes

storage temp.

2-8°C

Quality Level

100

Catégories apparentées

General description

Chemical structure: aminoglycoside

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.
Streptomycin solution has been used as a standard in the determination of streptomycin, present in honey using high performance liquid chromatography(HPLC).

Biochem/physiol Actions

Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.

Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.

Antimicrobial Spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.

Packaging

10ml

Preparation Note

This product contains 1 mg/mL Streptomycin in 1 mM EDTA and should be stored at 2-8°C.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Classe de stockage

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
BCCK2265
BCCG2612
BCCB9360
BCBV5142

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Validation of a high performance liquid chromatography (HPLC) method to detect and quantify some antibiotics residues in honey
Chebira B, et al.
Advances in Animal and Veterinary Sciences, 3, 295-301 (2015)
Jacqueline R Kemp et al.
Journal of molecular and cellular cardiology, 75, 25-39 (2014-07-01)
Improper regulation of signaling in vascular smooth muscle cells (VSMCs) by angiotensin II (AngII) can lead to hypertension, vascular hypertrophy and atherosclerosis. The extent to which the homeostatic levels of the components of signaling networks are regulated through microRNAs (miRNA)
Rabia T Khan et al.
PloS one, 9(2), e88009-e88009 (2014-02-08)
Experimental animal models of Salmonella infections have been widely used to identify genes important in the host immune response to infection. Using an F2 cross between the classical inbred strain C57BL/6J and the wild derived strain MOLF/Ei, we have previously
Puneet Gill et al.
Materials science & engineering. C, Materials for biological applications, 50, 37-44 (2015-03-10)
The constant demand for new implant materials and the multidisciplinary design approaches for stent applications have expanded vastly over the past decade. The biocompatibility of these implant materials is a function of their surface characteristics such as morphology, surface chemistry
Yajie Zhu et al.
International journal of oncology, 44(3), 896-904 (2014-01-09)
Previous studies have shown that RhoE, an atypical member of the Rho GTPase family, may play an opposite role to RhoA in regulating cell proliferation and invasion. To explore the relationship between RhoE and the malignant phenotypes of human cancer
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