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A7085

Acétaminophène

Name: Acétaminophène
Brand: SIAL

BioXtra, ≥99.0%

Synonyme(s) :

4′-Hydroxyacétanilide, 4-Acétaminophène, N-(4-Hydroxyphényl)acétamide, N-Acétyl-4-aminophénol, APAP, Paracétamol

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A propos de cet article

Formule linéaire :

CH₃CONHC₆H₄OH

Numéro CAS:

103-90-2

Poids moléculaire :

151.16

UNSPSC Code:

12352111

NACRES:

NA.25

PubChem Substance ID:

24891173

EC Number:

203-157-5

Beilstein/REAXYS Number:

2208089

MDL number:

MFCD00002328

Assay:

≥99.0%

Form:

powder

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Propriétés

product line

BioXtra

Quality Level

200

assay

≥99.0%

form

powder

impurities

≤0.0005% Phosphorus (P), ≤0.1% Insoluble matter

ign. residue

≤0.1%

mp

168-172 °C (lit.)

solubility

ethanol: 0.5 M, clear, colorless

anion traces

chloride (Cl^-): ≤0.05%, sulfate (SO₄^2-): ≤0.05%

cation traces

Al: ≤0.0005%, Ca: ≤0.0005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, NH₄⁺: ≤0.05%, Na: ≤0.005%, Pb: ≤0.001%, Zn: ≤0.0005%

SMILES string

CC(=O)Nc1ccc(O)cc1

InChI

1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

InChI key

RZVAJINKPMORJF-UHFFFAOYSA-N

Gene Information

human ... FAAH(2166), PTGS1(5742), PTGS2(5743), TRPV1(7442)

Description

General description

Acetaminophen or paracetamol is an analgesic and antipyretic. It is however a weak non opioid analgesic.

Application

Analgésique.

Acetaminophen has been used:

as an anti-inflammatory drug to test its effect in lipid peroxidation in marine mussels
to test its effect on neurite outgrowth in gamma-aminobutyric acid-ergic and glutamatergic neurons
as a hepatocellular injury inducing agent in mice

Biochem/physiol Actions

Acetaminophen or paracetamol is an inhibitor of prostaglandin synthesis. It is complexed with arachidonic acid in central nervous system resulting in the formation of N-arachidonoylphentolamine, which is essential for the activation of cannabinoid receptor. Acetaminophen is metabolized to toxic N-acetyl-p-benzoquinone imine. Paracetamol is prescribed for osteoarthritis pain and inhibits cyclooxygenase 1 and 2 activities. It is metabolized by the cytochrome P450 enzymes in liver and is implicated in liver toxicity.

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

364.3 °F - Pensky-Martens closed cup

flash_point_c

184.6 °C - Pensky-Martens closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Effects on feeding rate and biomarker responses of marine mussels experimentally exposed to propranolol and acetaminophen

Sole M, et al.

Analytical and Bioanalytical Chemistry, 396(2), 649-656 (2010)

Interactions between Acetaminophen and Phytotherapies: Overview for the Rational Use of Phytotherapics

Ribeiro J, et al.

Journal of Natural Product and Plant Resources, 8(3), 1-14 (2018)

Early detection of acute druginduced liver injury in mice by non-invasive NIR fluorescence imaging

Vasquez KO and Peterson JD

Journal of Pharmacology and Experimental Therapeutics, 1(4), 23-23 (2017)

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