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Merck

C2430000

Clotrimazole

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

1-(o-Chloro-α,α-diphenylbenzyl)imidazole, 1-(o-Chlorotrityl)imidazole, 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole

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A propos de cet article

Formule empirique (notation de Hill) :
C22H17ClN2
Numéro CAS:
23593-75-1
Poids moléculaire :
344.84
NACRES:
NA.24
PubChem Substance ID:
329775002
UNSPSC Code:
41116107
MDL number:
MFCD00057220

Principaux documents

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InChI

1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H

SMILES string

Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4

InChI key

VNFPBHJOKIVQEB-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

clotrimazole

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

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Catégories apparentées

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Clotrimazole EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

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Certificats d'analyse (COA)

Lot/Batch Number

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Natalia Mast et al.
Molecular pharmacology, 84(1), 86-94 (2013-04-23)
Although there are currently three generations of antifungal azoles on the market, even the third-generation agents show undesirable interactions with human cytochrome P450 (P450) enzymes. CYP46A1 is a cholesterol-metabolizing P450 in the brain that tightly binds a number of structurally
Sandra Gemma et al.
Journal of medicinal chemistry, 55(15), 6948-6967 (2012-07-13)
Despite recent progress in the fight against malaria, the emergence and spread of drug-resistant parasites remains a serious obstacle to the treatment of infections. We recently reported the development of a novel antimalarial drug that combines the 4-aminoquinoline pharmacophore of
Barbara A Miller et al.
American journal of physiology. Heart and circulatory physiology, 304(7), H1010-H1022 (2013-02-05)
The second member of the transient receptor potential-melastatin channel family (TRPM2) is expressed in the heart and vasculature. TRPM2 channels were expressed in the sarcolemma and transverse tubules of adult left ventricular (LV) myocytes. Cardiac TRPM2 channels were functional since
Michael B McFerrin et al.
American journal of physiology. Cell physiology, 303(10), C1070-C1078 (2012-09-21)
An important event during apoptosis is regulated cell condensation known as apoptotic volume decrease (AVD). Ion channels have emerged as essential regulators of this process mediating the release of K(+) and Cl(-), which together with osmotically obliged water, results in
Catherine L Neary et al.
Journal of cellular physiology, 228(9), 1943-1948 (2013-05-01)
Hexokinase II (HK2), the enzyme that catalyzes the first committed step of glycolysis, is overexpressed in many cancers, as is the central signaling kinase Akt. Akt activity promotes HK2 association with the mitochondria, as well as glucose uptake by cancer
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