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Merck

D8802

Dextran solution from Leuconostoc mesenteroides

20 % (w/w) (Autoclaved)

Synonyme(s) :

repeating α-linked D-glucopyranosyl units, synthesized from sucrose by Leuconostoc mesenteroides

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A propos de cet article

Numéro CAS:
9004-54-0
UNSPSC Code:
12352201
NACRES:
NA.75
MDL number:
MFCD00130935

Principaux documents

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SMILES string

O1C(C(C(C(C1CO)O)O)O)OCC2OC(C(C(C2O)O)O)OCC(O)C(O)C(O)C(O)C=O

InChI

1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2

InChI key

FZWBNHMXJMCXLU-UHFFFAOYSA-N

form

liquid

mol wt

average mol wt ~500,000

concentration

20 % (w/w) (Autoclaved)

technique(s)

titration: suitable

color

colorless

density

1.00-1.20 g/mL

application(s)

hematology
histology

storage temp.

2-8°C

Quality Level

200

Catégories apparentées

General description

Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, with a linear backbone of α-linked D-glucopyranosyl repeating units. Dextrans are found as bacterial extracellular polysaccharides. They are synthesized from sucrose by Leuconostoc mesenteroides. Bacteria employ dextran in biofilm formation or as a protective coating to evade host phagocytes in the case of pathogenic bacteria.

Application

Dextrans are used in many applications as platelet aggregants, plasma volume extenders, osmotic pressure regulators, stabilizers, organ separation media, matrix components, copolymers, microcarriers, binding agents, viscosity modifiers, antithrombotics, lubricants, and physical structure components.Dextran from Leuconostoc mesenteroides (Mw: 670,000) may be used as an analytical standard to calibrate the column for gel permeation chromatography (GPC). It has been used to sediment erythrocytes from blood along with 0.9% sodium chloride.

Use of dextrans as long and hydrophilic spacer arms to improve the performance of immobilized proteins acting on macromolecules.

Classe de stockage

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000332623
0000332623
0000259929
0000259918
SLCR3978

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Formyl Met-Leu-Phe-Stimulated FPR1 Phosphorylation in Plate-Adherent Human Neutrophils: Enhanced Proteolysis but Lack of Inhibition by Platelet-Activating Factor
Algirdas J, et al.
Journal of immunology research (2018)
Elizabeth M Bradshaw et al.
Nature neuroscience, 16(7), 848-850 (2013-05-28)
In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P(joint) = 1.3 × 10(-13)) of young
Ana Luisa Miranda-Vilela et al.
Journal of biomedical nanotechnology, 9(7), 1261-1271 (2013-08-06)
This work aimed to test a dextran-functionalized magnetic fluid (DexMF) sample in mediating magnetohyperthermia to treat an advanced clinical Ehrlich-solid-tumor, to verify the effects of oral antioxidant administration of pequi-oil on this treatment and to investigate the potential of these
R D Zysler et al.
Journal of biomedical nanotechnology, 9(1), 142-145 (2013-05-01)
We propose a new method for determining the quantity of superparamagnetic iron oxide nanoparticles (Fe3O4, SPIONs) embedded in animal tissue using magnetization measurements. With this method, the smallest detectable quantity of magnetite nanoparticles in a tissue sample is -1 microg.
Wai-Leung Langston Suen et al.
Investigative ophthalmology & visual science, 54(6), 4358-4365 (2013-06-01)
This study aims to determine the in vivo effectiveness of low-frequency ultrasound in mediating the transport of macromolecules to the posterior segment of the eye via transscleral route. It investigates if damage is caused by ultrasound at the tested operation
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