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Merck

I1762

Isoxicam

analytical standard

Synonyme(s) :

4-Hydroxy-2-methyl-N-5-methyl-3-isoxolyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide

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A propos de cet article

Formule empirique (notation de Hill) :
C14H13N3O5S
Numéro CAS:
34552-84-6
Poids moléculaire :
335.34
NACRES:
NA.24
PubChem Substance ID:
329815356
UNSPSC Code:
41116107
EC Number:
252-084-5
MDL number:
MFCD00079374

Principaux documents

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InChI key

YYUAYBYLJSNDCX-UHFFFAOYSA-N

InChI

1S/C14H13N3O5S/c1-8-7-11(16-22-8)15-14(19)12-13(18)9-5-3-4-6-10(9)23(20,21)17(12)2/h3-7,18H,1-2H3,(H,15,16,19)

SMILES string

CN1C(C(=O)Nc2cc(C)on2)=C(O)c3ccccc3S1(=O)=O

grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

200

Gene Information

human ... PTGS1(5742), PTGS2(5743)

Catégories apparentées

General description

Isoxicam is a long acting anti-inflammatory agent belonging to the oxicam group, and helps in relieving the symptoms of degenerative joint disease and rheumatoid arthritis. Its mode of action involves the ability to inhibit prostaglandin synthesis by suppressing the formation of cyclooxygenase and subsequent prostaglandin.

Application

Isoxicam may be used as an internal standard for the quantification of meloxicam in pharmaceutical preparations and as an analytical reference standard for the quantification of the analyte in biological samples using different analytical techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Classe de stockage

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Oxicams: metabolic disposition in man and animals.
T F Woolf et al.
Drug metabolism reviews, 21(2), 255-276 (1989-01-01)
E M Grace et al.
Current medical research and opinion, 10(9), 580-591 (1987-01-01)
Nineteen patients, aged 60 years and over, with rheumatoid arthritis participated in a clinical trial to investigate the pharmacokinetics of isoxicam (a new non-steroidal anti-inflammatory drug) in this age group. The purpose of the study was to determine if the
Flow injection chemiluminescence determination of isoxicam based on diperiodatoargentate (III)-fluorescein system in a micellar medium
Zhao F and Si H
Journal of Luminescence, 135(1), 259-264 (2013)
M Tariq
Research communications in chemical pathology and pharmacology, 60(1), 19-25 (1988-04-01)
The protective effect of some novel nonsteroidal anti-inflammatory agents has been studied on the endotoxin (lipopolysaccharide B) shock induced mortality in mice and biochemical changes in rats. All the three compounds included in this report, namely isoxicam, fentiazac and ketoprofen
M Esquivel et al.
Clinical and investigative medicine. Medecine clinique et experimentale, 10(5), 363-367 (1987-09-01)
To determine the effect of liver dysfunction on the absorption and disposition of isoxicam, we administered a single oral dose of 200 mg to 8 patients with alcoholic cirrhosis, and followed the plasma concentration-time curve for 96 h. The calculated
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