P7003
Piperazine hexahydrate
analytical standard
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A propos de cet article
Formule empirique (notation de Hill) :
C4H10N2 · 6H2O
Numéro CAS:
Poids moléculaire :
194.23
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
203-808-3
Beilstein/REAXYS Number:
4455527
MDL number:
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analytical standard
Quality Level
vapor pressure
0.8 mmHg ( 20 °C)
assay
≥99% (TLC)
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
bp
145-156 °C (lit.)
mp
42-44 °C (lit.)
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
SMILES string
[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].C1CNCCN1
InChI
1S/C4H10N2.6H2O/c1-2-6-4-3-5-1;;;;;;/h5-6H,1-4H2;6*1H2
InChI key
AVRVZRUEXIEGMP-UHFFFAOYSA-N
General description
Piperazine hexahydrate may be used as a standard for the determination of piperazine in pharmaceutical preparations using colorimetric technique.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
signalword
Danger
hcodes
Hazard Classifications
Repr. 2 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
Classe de stockage
8A - Combustible corrosive hazardous materials
wgk
WGK 1
flash_point_f
190.4 °F - closed cup
flash_point_c
88 °C - closed cup
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Colorimetric determination of piperazine in pharmaceutical formulations
Dessouky M Y and Ismaiel A S.
Analyst, 99(1181), 482-486 (1974)
Juneha Bak et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 36(10), 1269-1274 (2020-06-23)
Sulfated saccharides exhibit diverse physiological activities, but a lack of any convenient assay hinders their evaluation. Herein, an assay for the analysis of sulfated saccharides is described using 1H nuclear magnetic resonance (NMR) spectroscopy by employing ligands that can form
Yuji Nakamura et al.
Bioorganic & medicinal chemistry letters, 22(14), 4561-4566 (2012-06-26)
Introduction of the 2,2-dimethyl-4-phenylpiperazin-5-one scaffold into the P(3)-P(1) portion of the (2S,4S,5S)-5-amino-6-dialkylamino-4-hydroxy-2-isopropylhexanamide backbone dramatically increased the renin inhibitory activity without using the interaction to the S(3)(sp) pocket. Compound 31 exhibited >10,000-fold selectivity over other human proteases, and 18.5% oral bioavailability