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Merck

PHR1416

Citrate de sodium

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

Citrate de sodium tribasique dihydrate, Acide citrique trisodium salt dihydrate, Citrate trisodique dihydrate

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A propos de cet article

Formule linéaire :
HOC(COONa)(CH2COONa)2 · 2H2O
Numéro CAS:
6132-04-3
Poids moléculaire :
294.10
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823386
EC Number:
200-675-3
Beilstein/REAXYS Number:
6104939
MDL number:
MFCD00150031

Principaux documents

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InChI

1S/C6H8O7.3Na.2H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;2*1H2/q;3*+1;;/p-3

InChI key

NLJMYIDDQXHKNR-UHFFFAOYSA-K

SMILES string

O.O.[Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1613859

API family

sodium citrate

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

>300 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Catégories apparentées

General description

Sodium citrate, also known as E331, is a tri-sodium salt of citric acid. In food products, it is commonly used as a flavor and preservative. In pharmaceutical formulations, it is used as a buffer, emulsifier and sequestering agent.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Sodium citrate may be used as a pharmaceutical reference standard for the determination of the analyte in raw material, food and pharmaceutical formulations by titrimetry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3037 in the slot below. This is an example certificate only and may not be the lot that you receive.

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Sodium citrate
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3574-3574 (2017)
Sodium citrate
Handbook of Pharmaceutical Excipients 6th edition Pharmaceutical Press, 640-642 (2009)
Sodium citrate
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 4069-4069 (2018)
Sara Svensson et al.
International journal of nanomedicine, 9, 775-794 (2014-02-20)
The role of material surface properties in the direct interaction with bacteria and the indirect route via host defense cells is not fully understood. Recently, it was suggested that nanostructured implant surfaces possess antimicrobial properties. In the current study, the
Kirsten Balvers et al.
Shock (Augusta, Ga.), 43(4), 317-321 (2015-01-08)
Severe trauma affects the immune system, which in its turn is associated with poor outcome. The mediators driving the immune responses in trauma are largely unknown. The aim of this study was to investigate the role of endogenous microparticles (MPs)
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