RDD035
HEPES sodium salt
≥99.5% (titration), free-flowing, Redi-Dri™
Synonyme(s) :
Acide 4-(2-hydroxyéthyl)pipérazine-1-éthanesulfonique sodium salt, Acide N-(2-hydroxyéthyl)pipérazine-N′-(2-éthanesulfonique) sodium salt
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A propos de cet article
Formule empirique (notation de Hill) :
C8H17N2NaO4S
Numéro CAS:
Poids moléculaire :
260.29
UNSPSC Code:
12161700
NACRES:
NA.25
MDL number:
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Redi-Dri™
Quality Level
assay
≥99.5% (titration)
quality
free-flowing
useful pH range
6.8-8.2
pKa (25 °C)
7.5
application(s)
diagnostic assay manufacturing
SMILES string
[Na+].OCCN1CCN(CC1)CCS([O-])(=O)=O
InChI
1S/C8H18N2O4S.Na/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14;/h11H,1-8H2,(H,12,13,14);/q;+1/p-1
InChI key
RDZTWEVXRGYCFV-UHFFFAOYSA-M
General description
HEPES sodium salt is essential to prepare HEPES buffer that is commonly used for cell culture and protein applications. It is useful for maintaining homeostasis when working with cells outside of the incubator by balancing CO2. HEPES buffering capacity exceeds most buffers, with a pKa of 7.5, making it optimal for maintaining pH in biological systems. In solution, it is non-toxic, zwitterion with a physiological buffering range of pH 6.8 - 8.2. It has a low metal binding capacity and is safe to use in research for metal-binding proteins.
Application
HEPES sodium salt can be used:
- as a protein precipitation buffer
- in cell culture media
- as a binding buffer
Features and Benefits
- Redi-Dri™ eliminates clumping for hygroscopic chemicals
- powder remains free-flowing and easy to use
- Safer to handle and weigh out for standard use in lab
- Eliminates clumps, maintains product moisture, quality, and characteristics
Physical form
Lyophilized, spray dried, or crystallized material.
Other Notes
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Legal Information
Redi-Dri is a trademark of Sigma-Aldrich Co. LLC
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Classe de stockage
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Nishant Mehta et al.
Cell reports, 28(10), 2509-2516 (2019-09-05)
V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA) is an immune checkpoint protein that inhibits the T cell response against cancer. Similar to PD-1 and CTLA-4, a blockade of VISTA promotes tumor clearance by the immune system. Here, we report a
Jihye Park et al.
The Analyst, 137(19), 4411-4414 (2012-08-07)
We have developed a quickly responsive, and specific fluorescent assay for the detection of Au(III) on the basis of the formation of gold nanoparticles in the presence of HEPES, which cleave the C-I bond of I-BODIPY 1 to yield the
S Hugel et al.
British journal of pharmacology, 166(8), 2402-2416 (2012-03-29)
Artificial buffers such as HEPES are extensively used to control extracellular pH (pH(e) ) to investigate the effect of H(+) ions on GABA(A) receptor function. In neurones cultured from spinal cord dorsal horn (DH), dorsal root ganglia (DRG) and cerebellar