31404
Sulfate de dextran sodium salt from Leuconostoc spp.
Mr 5,000
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(Leuconostoc spp.)
Quality Level
form
powder
mol wt
Mr 5,000
composition
Sulfur Content, 16.0-20.0%
loss
≤10% loss on drying
useful pH range
6.0-8.0 (10 g/L)
solubility
H2O: 0.1 g/mL, clear, colorless to slightly yellow, water: 100 g/L at 25 °C (77 °F ), H2O: freely soluble 50 mg/mL, clear
storage temp.
room temp
Application
Dextran sulfate sodium salt from Leuconostoc sp. is a polyanion used as a test reagent for testing its capability to rupture the extracellular enveloped virus (EEV) outer membrane. It has also been used for assessing the impact of TLR4 monoclonal antibody on the growth of dextran-sulfate-sodium-(DSS)-induced colitis.
Biochem/physiol Actions
Dextran is a mixture of glucose polymers of varying size and geometry.Dextran in the form of dextran sulphate sodium acts as an anticoagulant. Dextran interferes with blood clot formation by acting on blood coagulation factors and the function of platelets. It prolongs the time required for formation of the clot and decreases the maximum clot strength. The disturbance of homeostasis by dextran may cause increased bleeding, colitis and kidney failure.
Preparation Note
prepared from dextran with Mr ~5000
Other Notes
To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.
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Classe de stockage
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Contenu apparenté
Yi Liu et al.
Journal of gastroenterology and hepatology, 25(1), 209-214 (2009-11-26)
Ulcerative colitis (UC) refers to a kind of inflammatory bowel disease, of which the accurate pathogenesis is not yet well understood. Recently, the toll-like receptor 4 (TLR4) and the TLR4 signaling pathway have been proved as playing an important role
Prevention of venous thromboembolism.
G P Clagett et al.
Chest, 108(4 Suppl), 312S-334S (1995-10-01)
Simon Finfer et al.
The New England journal of medicine, 350(22), 2247-2256 (2004-05-28)
It remains uncertain whether the choice of resuscitation fluid for patients in intensive care units (ICUs) affects survival. We conducted a multicenter, randomized, double-blind trial to compare the effect of fluid resuscitation with albumin or saline on mortality in a