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Merck

44611

Durcupan ACM

single component A, M epoxy resin

Synonyme(s) :

ACM resins

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A propos de cet article

UNSPSC Code:
13111001
NACRES:
NA.25
MDL number:
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Nom du produit

Durcupan ACM, single component A, M epoxy resin

impurities

bisphenol A epoxy resin

Quality Level

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Application

DurcupanACM, single component A, M epoxy resin has been used for:
  • A method to prepare large resin sections for counting myelinated axons in rodent CNS and PNS structures.: This study presents a technique using Durcupan ACM for preparing large resin sections, enhancing the analysis of myelinated axons in rodent central and peripheral nervous systems.
  • Three-dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues.: This research utilizes Durcupan ACM in electron microscopy to create 3D models of neural tissues, facilitating studies via immersive virtual reality.
  • Long-term effect of prazosin and losartan administration on blood pressure, heart, carotid artery, and acetylcholine induced dilation of cardiovascular system of young Wistar rats and SHR.: Explores the cardiovascular effects in rats using Durcupan ACM embedded samples for detailed tissue analysis.
  • Embedding material for electron microscopy on the basis of Araldite®.

Features and Benefits

Mixtures of Durcupan ACM present an interesting alternative to methacrylates for embedding sections for electron microscopy. They present the advantage that they harden uniformly, practically without shrinkage. All fixing agents normally used for electronmicroscopic work are also suitable for the Durcupan ACM embedding process. This process consists of three phases: dehydration of the tissue with acetone or ethyl alcohol, infiltration with the embedding agent, followed by hardening.

General description

Awater-soluble embedding medium for EM based on an aliphatic polyepoxide.

Legal Information

Araldite is a registered trademark of Huntsman Advanced Materials Inc.
Durcupan is a trademark of Sigma-Aldrich Chemie GmbH

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Warning

Hazard Classifications

Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Classe de stockage

10 - Combustible liquids

wgk

WGK 2

flash_point_f

377.6 °F

flash_point_c

192 °C

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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A method to prepare large resin sections for counting myelinated axons in rodent CNS and PNS structures
Dzurjaskova Z, et al.
Neuroscience Letters, 750, 135767-135767 (2021)
Long-term effect of prazosin and losartan administration on blood pressure, heart, carotid artery, and acetylcholine induced dilation of cardiovascular system of young Wistar rats and SHR
Kristek F, et al.
General Physiology and Biophysics, 32(2), 235?243-235?243 (2013)
Three-dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues
Cali C, et al.
The Journal of Comparative Neurology, 524(1), 23-38 (2016)
Tin Ki Tsang et al.
eLife, 7 (2018-05-12)
Electron microscopy (EM) offers unparalleled power to study cell substructures at the nanoscale. Cryofixation by high-pressure freezing offers optimal morphological preservation, as it captures cellular structures instantaneously in their near-native state. However, the applicability of cryofixation is limited by its
Jinzhong Zhang et al.
Autophagy, 15(10), 1738-1756 (2019-03-21)
Several lines of evidence support the occurrence of cross-regulation between the endocytic pathway and autophagy, but the molecular mechanisms regulating this process are not well-understood. Here, we show that the calcium sensor UNC13D regulates the molecular mechanism of late endosomal

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