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Durcupan™ ACM
single component C, accelerator 960 (DY 060)
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Durcupan™ ACM, single component C, accelerator 960 (DY 060)
Quality Level
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Application
Durcupan™ACM, single component C, accelerator 960 (DY 060) has been used for:
- A method to prepare large resin sections for counting myelinated axons in rodent CNS and PNS structures.: This study presents a technique using Durcupan ACM for preparing large resin sections, enhancing the analysis of myelinated axons in rodent central and peripheral nervous systems.
- Three-dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues.: This research utilizes Durcupan ACM in electron microscopy to create 3D models of neural tissues, facilitating studies via immersive virtual reality.
- Long-term effect of prazosin and losartan administration on blood pressure, heart, carotid artery, and acetylcholine induced dilation of cardiovascular system of young Wistar rats and SHR.: Explores the cardiovascular effects in rats using Durcupan ACM embedded samples for detailed tissue analysis.
- Embedding material for electron microscopy on the basis of Araldite®.
Features and Benefits
Mixtures of Durcupan ACM present an interesting alternative to methacrylates for embedding sections for electron microscopy. They present the advantage that they harden uniformly, practically without shrinkage. All fixing agents normally used for electronmicroscopic work are also suitable for the Durcupan ACM embedding process. This process consists of three phases: dehydration of the tissue with acetone or ethyl alcohol, infiltration with the embedding agent, followed by hardening.
General description
Awater-soluble embedding medium for EM based on an aliphatic polyepoxide.
Legal Information
Araldite is a registered trademark of Huntsman Advanced Materials Inc.
Durcupan is a trademark of Sigma-Aldrich Chemie GmbH
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Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
Classe de stockage
8A - Combustible, corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Long-term effect of prazosin and losartan administration on blood pressure, heart, carotid artery, and acetylcholine induced dilation of cardiovascular system of young Wistar rats and SHR
Kristek F, et al.
General Physiology and Biophysics, 32(2), 235?243-235?243 (2013)
Three-dimensional immersive virtual reality for studying cellular compartments in 3D models from EM preparations of neural tissues
Cali C, et al.
The Journal of Comparative Neurology, 524(1), 23-38 (2016)
A method to prepare large resin sections for counting myelinated axons in rodent CNS and PNS structures
Dzurjaskova Z, et al.
Neuroscience Letters, 750, 135767- 135767 (2021)
Tin Ki Tsang et al.
eLife, 7 (2018-05-12)
Electron microscopy (EM) offers unparalleled power to study cell substructures at the nanoscale. Cryofixation by high-pressure freezing offers optimal morphological preservation, as it captures cellular structures instantaneously in their near-native state. However, the applicability of cryofixation is limited by its
David E Gordon et al.
Molecular cell, 78(2), 197-209 (2020-02-23)
We have developed a platform for quantitative genetic interaction mapping using viral infectivity as a functional readout and constructed a viral host-dependency epistasis map (vE-MAP) of 356 human genes linked to HIV function, comprising >63,000 pairwise genetic perturbations. The vE-MAP
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