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Merck

46043

Ethidium homodimer

suitable for fluorescence, ~90% (HPCE)

Synonyme(s) :

EtDi, EthD-1

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About This Item

Formule empirique (notation de Hill) :
C46H50Cl4N8
Numéro CAS:
61926-22-5
Poids moléculaire :
856.75
NACRES:
NA.32
PubChem Substance ID:
329757072
UNSPSC Code:
12161505
EC Number:
263-325-9
MDL number:
MFCD00210948

Nom du produit

Ethidium homodimer, suitable for fluorescence, ~90% (HPCE)

InChI key

ZKAJUKABUUJRLB-UHFFFAOYSA-N

InChI

1S/C46H46N8.4ClH/c47-33-13-17-37-39-19-15-35(49)29-43(39)53(45(41(37)27-33)31-9-3-1-4-10-31)25-7-21-51-23-24-52-22-8-26-54-44-30-36(50)16-20-40(44)38-18-14-34(48)28-42(38)46(54)32-11-5-2-6-12-32;;;;/h1-6,9-20,27-30,49-52H,7-8,21-26,47-48H2;4*1H

SMILES string

Cl.Cl.[Cl-].[Cl-].Nc1ccc2c(c1)c(-c3ccccc3)[n+](CCCNCCNCCC[n+]4c(-c5ccccc5)c6cc(N)ccc6c7ccc(N)cc47)c8cc(N)ccc28

Quality Level

100

description

suitable for the fluorogenic detection of DNA

assay

~90% (HPCE)

form

solid

mol wt

856.75 g/mol

concentration

≤100% (5,5′-[Ethylenebis(iminotrimethylene)]bis[3,8-diamino-6-phenylphenanthridinium] dichloride dihydrochloride)

color

red to dark red

mp

≥250 °C (lit.)

solubility

DMF: soluble
DMSO: soluble
H2O: soluble

fluorescence

λex 493 nm in H2O
λex 528 nm; λem 617 nm in TE buffer; DNA

suitability

suitable for fluorescence

storage temp.

−20°C

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Catégories apparentées

Application

Ethidium homodimer (EtDi, EthD-1) is used as a staining dye for ssDNA, dsDNA, RNA, oligonucleotides, and triplex DNA. EthD-1 does not cross intact/viable cell membranes and can be used to test cell viability.
Staining dye for ssDNA, dsDNA, RNA, oligonucleotides, and triplex DNA. It will not cross intact cell membranes and can be used to test cell viability.

Other Notes

Reagent for the fluorimetric detection of nucleic acids

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

signalword

Danger

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Skin Corr. 1B - Water-react 3

Classe de stockage

4.3 - Hazardous materials which set free flammable gases upon contact with water

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
BCCM9592
BCCL6112
BCCK6197
BCCH3824
BCCJ2825

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Ethidium dimer: a new reagent for the fluorimetric determination of nucleic acids.
J Markovits et al.
Analytical biochemistry, 94(2), 259-264 (1979-04-15)
Susanne Radonjic-Hoesli et al.
The Journal of allergy and clinical immunology, 140(6), 1632-1642 (2017-04-17)
Eosinophils are a subset of granulocytes that can be involved in the pathogenesis of different diseases, including allergy. Their effector functions are closely linked to their cytotoxic granule proteins. Release takes place through several different mechanisms, one of which is
Nai-Chen Cheng et al.
Acta biomaterialia, 51, 258-267 (2017-01-31)
Adipose-derived stem cells (ASCs) secrete several angiogenic growth factors and can be applied to treat ischemic tissue. However, transplantation of dissociated ASCs has frequently resulted in rapid cell death. Therefore, we aimed to develop a thermosensitive chitosan/gelatin hydrogel that is
Takeichiro Nakane et al.
Scientific reports, 7, 45641-45641 (2017-04-04)
The current study describes a scalable, porous large-format engineered cardiac tissue (LF-ECT) composed of human induced pluripotent stem cells (hiPSCs) derived multiple lineage cardiac cells with varied 3D geometries and cell densities developed towards the goal of scale-up for large
X R Mao et al.
Cell death & disease, 7, e2113-e2113 (2016-02-26)
Gain-of-function mutations in the mouse nicotinamide mononucleotide adenylyltransferase type 1 (Nmnat1) produce two remarkable phenotypes: protection against traumatic axonal degeneration and reduced hypoxic brain injury. Despite intensive efforts, the mechanism of Nmnat1 cytoprotection remains elusive. To develop a new model
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