53467
2,3-Dioleyloxy-1-(dimethylamino)propane
≥98.0% (TLC)
Synonyme(s) :
1,2-Dioleyloxy-3-(dimethylamino)propane, N,N-Dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine, DODMA
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A propos de cet article
Formule empirique (notation de Hill) :
C41H81NO2
Numéro CAS:
Poids moléculaire :
620.09
UNSPSC Code:
12352211
NACRES:
NA.85
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
10139013
Service technique
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Laissez-nous vous aiderbiological source
synthetic
Quality Level
assay
≥98.0% (TLC)
form
liquid
functional group
amine, ether
lipid type
cationic lipids
storage temp.
−20°C
SMILES string
CCCCCCCC\C=C/CCCCCCCCOCC(CN(C)C)OCCCCCCCC\C=C/CCCCCCCC
InChI
1S/C41H81NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-43-40-41(39-42(3)4)44-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h19-22,41H,5-18,23-40H2,1-4H3/b21-19-,22-20-
InChI key
GLGLUQVVDHRLQK-WRBBJXAJSA-N
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Classe de stockage
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids.
Heyes, J., et al.
J. Controlled Release, 107, 276-287 (2005)
Lloyd B Jeffs et al.
Pharmaceutical research, 22(3), 362-372 (2005-04-20)
A fully scalable and extrusion-free method was developed to prepare rapidly and reproducibly stabilized plasmid lipid particles (SPLP) for nonviral, systemic gene therapy. Liposomes encapsulating plasmid DNA were formed instantaneously by mixing lipids dissolved in ethanol with an aqueous solution
Single-step microfluidic synthesis of transferrin-conjugated lipid nanoparticles for siRNA delivery.
Yujing Li et al.
Nanomedicine : nanotechnology, biology, and medicine, 13(2), 371-381 (2016-10-18)
Microfluidic systems can accelerate clinical translation of nanoparticles due to their ability to generate nanoparticles in a well-controlled and reproducible manner. In this study, a single-step process based on microfluidic focusing (MF) was employed to synthesize transferrin-conjugated lipid nanoparticles (Tf-LNPs)