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Merck

A2504

6-Aminocaproic acid

≥99% (titration), powder

Synonyme(s) :

ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA

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A propos de cet article

Formule linéaire :
H2N(CH2)5CO2H
Numéro CAS:
60-32-2
Poids moléculaire :
131.17
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
24890662
EC Number:
200-469-3
Beilstein/REAXYS Number:
906872
MDL number:
MFCD00008238
Assay:
≥99% (titration)
Form:
powder

Principaux documents

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Nom du produit

6-Aminocaproic acid, ≥99% (titration), powder

color

white

InChI key

SLXKOJJOQWFEFD-UHFFFAOYSA-N

InChI

1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)

SMILES string

NCCCCCC(O)=O

biological source

synthetic

assay

≥99% (titration)

form

powder

technique(s)

cell culture | mammalian: suitable

mp

207-209 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

Quality Level

300

Gene Information

human ... PLAT(5327), PLG(5340)
rat ... Ppm1a(24666)

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Catégories apparentées

Application

EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.

Biochem/physiol Actions

EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo­xy­peptidase, plasmin, and plasminogen activator.
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis.
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.

Classe de stockage

11 - Combustible Solids

wgk

WGK 2

flash_point_f

404.6 - 408.2 °F

flash_point_c

207 - 209 °C

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
0000528082
0000528082
0000491402
0000515854
0000491402

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Kazuki Yamamoto et al.
Lab on a chip, 21(10), 1897-1907 (2021-05-20)
Engineered three-dimensional models of neuromuscular tissues are promising for use in mimicking their disorder states in vitro. Although several models have been developed, it is still challenging to mimic the physically separated structures of motor neurons (MNs) and skeletal muscle
E M Van Hoeyveld et al.
The Journal of allergy and clinical immunology, 76(4), 543-550 (1985-10-01)
The effect of epsilon-aminocaproic acid (EACA) on the degradation of an aqueous Lolium perenne extract was studied by intracutaneous tests and by RAST inhibition. Extracts for skin testing stored at 4 degrees C for 12 months and at 37 degrees
Ai Kia Yip et al.
Biophysical journal, 104(1), 19-29 (2013-01-22)
Cells sense the rigidity of their substrate; however, little is known about the physical variables that determine their response to this rigidity. Here, we report traction stress measurements carried out using fibroblasts on polyacrylamide gels with Young's moduli ranging from
Brian Hutton et al.
BMJ (Clinical research ed.), 345, e5798-e5798 (2012-09-13)
To estimate the relative risks of death, myocardial infarction, stroke, and renal failure or dysfunction between antifibrinolytics and no treatment following the suspension of aprotinin from the market in 2008 for safety reasons and its recent reintroduction in Europe and
Moamen Bydoun et al.
Molecular oncology, 12(11), 1895-1916 (2018-07-17)
Pancreatic cancer is arguably the deadliest cancer type. The efficacy of current therapies is often hindered by the inability to predict patient outcome. As such, the development of tools for early detection and risk prediction is key for improving outcome
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Contenu apparenté

Product Information Sheet - A2504

Product Information Sheet

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