A2731
AMG 9810
≥98% (HPLC), powder
Synonyme(s) :
2E-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-Propenamide
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A propos de cet article
Formule empirique (notation de Hill) :
C21H23NO3
Numéro CAS:
Poids moléculaire :
337.41
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352203
MDL number:
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assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >5 mg/mL
originator
Amgen
storage temp.
2-8°C
SMILES string
CC(C)(C)c1ccc(\C=C\C(=O)Nc2ccc3OCCOc3c2)cc1
InChI
1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+
InChI key
GZTFUVZVLYUPRG-IZZDOVSWSA-N
Biochem/physiol Actions
AMG 9810 is a potent, non-vanilloid, antagonist of the TRPV1 receptor. IC50 = 17 nM.
AMG 9810 is the cinnamide TRPV1 (vanilloid receptor 1) antagonist, that can prevent eye wiping behavior, stimulated by capsaicin and can inverse hyperalgesia in an animal model of inflammatory pain. It possesses antihyperalgesic properties.
Features and Benefits
This compound was developed by Amgen. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 4
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Elham Hakimizadeh et al.
Iranian journal of basic medical sciences, 15(3), 795-802 (2013-03-16)
Fatty acid is amide hydrolase which reduce endogenous anandamide. Transient receptor potential vanilloid-1 (TRPV1) channels have been reported to have a role in the modulation of anxiety-like behaviors in rodents. In the present study, the effects of either endocannabinoid system
Mark H Pitcher et al.
Molecular pain, 3, 17-17 (2007-07-03)
The Na+, K+, 2Cl- type I cotransporter (NKCC1) and TRPV1 receptors, at the level of the dorsal horn, have been implicated in mediating allodynia in response to an inflammatory insult. The NKCC1 cotransporter regulates intracellular [Cl-] and thus the magnitude
Michele Hummel et al.
World journal of gastroenterology, 23(33), 6065-6076 (2017-10-04)
To evaluate whether non-steroidal anti-inflammatory drugs (NSAIDs)-induced gastropathy is a clinically predictive model of referred visceral hypersensitivity. Gastric ulcer pain was induced by the oral administration of indomethacin to male, CD1 mice ( Results showed that two opioids and a