A3286
N-Acétyl-D-glucosamine
suitable for cell culture, BioReagent
Synonyme(s) :
2-Acétamido-2-désoxy-D-glucose, D-GlcNAc
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A propos de cet article
Formule empirique (notation de Hill) :
C8H15NO6
Numéro CAS:
Poids moléculaire :
221.21
UNSPSC Code:
12352201
NACRES:
NA.75
PubChem Substance ID:
EC Number:
231-368-2
Beilstein/REAXYS Number:
1727589
MDL number:
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BioReagent
assay
≥95% (HPLC)
form
powder
technique(s)
cell culture | mammalian: suitable
mp
211 °C (dec.) (lit.)
storage temp.
−20°C
Quality Level
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General description
N-Acetylglucosamine (GlcNAc), a derivative of glucose is a monosaccharide. It is a white powder and is mildly sweet. It melts at 221°C. GlcNAc is 25% soluble in water. It is present in bromelain, ricin agglutinin and abrus agglutinin, in plants. In humans, it is present in tissue plasminogen activator, growth factors and hormones.
Application
N-Acetyl-D-glucosamine addition has been used:
- as a substrate to develop dot-blots
- as a substrate to reveal alkaline phosphatase in the immunohistochemical analysis
- to detect specific immune complexes in western blot analysis
Biochem/physiol Actions
N-Acetylglucosamine (GlcNAc) oligomer may have the ability to initiate factors for canine polymorphonuclear cells (PMN) in vivo. It possesses wound healing and chemotactic activity. GlcNAc and its derivatives are usually employed in preparing dietary supplements and also used in therapeutic development.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence
Gitenay D, et al.
Cell Death & Disease, 5(2), e1089-e1089 (2014)
Cumulus expansion, nuclear maturation and connexin 43, cyclooxygenase-2 and FSH receptor mRNA expression in equine cumulus-oocyte complexes cultured in vitro in the presence of FSH and precursors for hyaluronic acid synthesis
Dell'Aquila M E, et al.
Reproductive Biology and Endocrinology, 2(1), 44-44 (2004)
Effect of N-acetyl-d-glucosamine and d-glucosamine oligomers on canine polymorphonuclear cells in vitro
Usami Y, et al.
Carbohydrate Polymers, 36(2-3), 137-141 (1998)
Glycoprofiling effects of media additives on IgG produced by CHO cells in fed-batch bioreactors
Kildegaard H F, et al.
Biotechnology and Bioengineering, 113(2), 359-366 (2016)
Lucy G Weaver et al.
Carbohydrate research, 371, 68-76 (2013-03-26)
Poly-N-acetylglucosamine (PNAG) saccharides are an important constituent of bacterial biofilms, such as those produced by Staphylococcus aureus. We have developed a simple two-step iterative method for the synthesis of β-(1→6)-glucosamine oligosaccharides that are structurally similar to PNAG. We illustrate the
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