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Merck

A5486

Azoxyméthane

13.4 M, ≥98%

Synonyme(s) :

AOM

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A propos de cet article

Formule linéaire :
CH3N=N(→O)CH3
Numéro CAS:
25843-45-2
Poids moléculaire :
74.08
NACRES:
NA.25
PubChem Substance ID:
329770827
UNSPSC Code:
12352124
MDL number:
MFCD00126912
Assay:
≥98%
Form:
liquid
Quality level:
200
Storage condition:
(Keep container tightly closed in a dry and well-ventilated place.)

Principaux documents

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InChI key

DGAKHGXRMXWHBX-ONEGZZNKSA-N

SMILES string

C\N=[N+](/C)[O-]

InChI

1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+

assay

≥98%

form

liquid

composition

methylene chloride, ≤1%

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

concentration

13.4 M

color

colorless

bp

97-99 °C (lit.)

density

0.991 g/mL at 25 °C (lit.)

application(s)

genomic analysis

storage temp.

−20°C

Quality Level

200

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General description

L'azoxyméthane (AOM) est un produit chimique de laboratoire puissant servant à étudier l'initiation, la progression et la prévention du cancer, en particulier dans le côlon. C'est à la fois un agent cancérigène qui déclenche la formation de tumeurs, et un agent mutagène qui provoque des altérations spécifiques dans l'ADN.

Application

L′azoxyméthane (AOM), agent provoquant des mutations de l′ADN, peut être utilisé avec le sulfate de dextrane sodique (DSS) pour créer des modèles du cancer dans des animaux de laboratoire en vue d′étudier les mécanismes de progression et de chimioprévention du cancer.

Biochem/physiol Actions

Cancérigène qui induit la formation d′adduits O6-méthylguanine dans l′ADN qui mènent à des transitions G→A. Il induit une tumorigenèse dans le côlon d′animaux de laboratoire et est utilisé pour étudier le mécanisme de progression tumorale et de chimioprévention.

Features and Benefits

Produit polyvalent et pouvant s'adapter à un large éventail d'applications de laboratoire et de recherche.

Other Notes

Il est essentiel de déterminer la concentration correcte d′azoxyméthane dans le schéma expérimental pour éviter la mort prématurée des animaux de laboratoire.
Pour de plus amples informations sur notre gamme de Produits biochimiques, merci de compléter ce formulaire.

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Danger

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

Classe de stockage

3 - Flammable liquids

wgk

WGK 3

flash_point_f

75.2 °F

flash_point_c

24 °C

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Certificats d'analyse (COA)

Lot/Batch Number
0000515941
0000515941
0000503884
0000503882
0000503884

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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. What solvents can be used to dissolve Azoxymethane?

    Azoxymethane is soluble in water, ether, ethanol, and chloroform. The reported solubility in chlorform is 200 mg/mL, and in water is 100 mg/mL.

  7. How should stock solutions of Azoxymethane be stored, and for how long can they be kept?

    No solution stability studies have been performed by Sigma-Aldrich. Because the solution stability is unknown, solutions should be prepared fresh for use.

  8. How does azoxymethane act to cause cancers?

    Azoxymethane is a methylating agent which forms 6-O-methylguanine in DNA.  Unless this methylated base is repaired by cellular enzymes, it results in a base mismatch that subsequently causes tumors in the tissue.

  9. What are the approximate volumes for the of 25 mg and 100 mg, package sizes of Product No. A5486, Azoxymethane?

    Using the literature value for density of approximately 0.991 g/mL (at 25 °C), the approximate volumes are 25 μL for the 25 mg package size and 100 μl for the 100 mg package size.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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