A5843
Albumine from human serum
lyophilized powder, low endotoxin
Synonyme(s) :
HSA
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About This Item
Numéro CAS:
UNSPSC Code:
12352202
eCl@ss:
42010201
EC Number:
274-272-6
NACRES:
NA.25
MDL number:
Nom du produit
Albumine from human serum, lyophilized powder, low endotoxin
SMILES string
FC(F)(F)C(F)(F)C(F)(F)F
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
InChI key
QYSGYZVSCZSLHT-UHFFFAOYSA-N
biological source
human
assay
≥96% (agarose gel electrophoresis)
form
lyophilized powder
mol wt
monomer calculated mol wt 66478 Da
technique(s)
activity assay: suitable
impurities
HIV I and HIVII, HCV and HBsAg, tested negative
≤1.0 EU/mg endotoxin
solubility
H2O: soluble 50 mg/mL
UniProt accession no.
storage temp.
2-8°C
Quality Level
Gene Information
human ... ALB(213)
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Biochem/physiol Actions
Les albumines sont des protéines monomériques solubles présentes dans les liquides biologiques et les tissus animaux ainsi que dans certaines semences de plantes. L′albumine sérique fonctionne en tant que protéine porteuse des stéroïdes, acides gras et hormones thyroïdes. Les albumines sériques sont également essentielles à la régulation de la pression colloïde osmotique du sang.
L′albumine sérique fonctionne en tant que protéine porteuse des stéroïdes, acides gras et hormones thyroïdes, et est essentielle à la régulation de la pression colloïde osmotique du sang. L′albumine est également capable de se lier à certaines substances exogènes, en particulier les médicaments (p. ex., ibuprofène, warfarine) et influence fortement leurs propriétés pharmacocinétiques. Le stress oxydant, qui entraîne des changements de l′état d′oxydoréduction de l′albumine, exerce des effets divers sur sa fonction physiologique.
Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones, and is vital in regulating the colloidal osmotic pressures of blood. Albumin is also seen to bind to exogenous substances, particularly drugs (e.g., ibuprofen, warfarin), and strongly influences their pharmacokinetics. Oxidative stress leading to changes in the redox state of albumin has varied effects on its physiological function.
Other Notes
Obtenir de plus amples informations sur l′albumine sérique humaine.
Application
Albumin was used to test its effect on the in vitro bactericidal activity of cefditoren against penicillin-resistant Streptococcus pneumonia. It has been clinically used in serious and often life-threatening conditions, such as shock and blood loss due to trauma, burns, and surgery.
Albumin was used to study albumin-induced apoptosis in proximal tubule cells. It was also used in cell adhesion molecules and surface treatment studies.
Albumin was used to study albumin-induced apoptosis in proximal tubule cells. It was also used in cell adhesion molecules and surface treatment studies.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
General description
Albumin is the most copious protein in blood plasma. Liver produces human albumin.
Classe de stockage
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
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Sam Coffey et al.
PloS one, 10(10), e0140417-e0140417 (2015-10-16)
Diabetes mellitus (DM) has become an epidemic, causing a significant decline in quality of life of individuals due to its multisystem involvement. Kidney is an important target organ in DM accounting for the majority of patients requiring renal replacement therapy
Edina Korça et al.
Scientific reports, 10(1), 17105-17105 (2020-10-15)
Advanced glycation endproducts (AGEs) are formed in a series of non-enzymatic reactions between reducing sugars and the amino groups of proteins and accumulate during aging, diabetes mellitus, chronic kidney disease and other chronic diseases. Accumulation of AGE-modifications alters protein structure
Qiong Wen et al.
Nephrology (Carlton, Vic.), 15(1), 63-74 (2010-04-10)
SUMMARY AT A GLANCE Patients with MCD and FSGS had significant changes in the expression of several EMT-related urinary proteins through activation ERK1/2 and p38 signaling pathways. Further studies to explore the molecular mechanisms behind the distinct clinical features of
Miranda J Ridder et al.
Infection and immunity, 88(8) (2020-06-10)
Staphylococcus aureus fatty acid kinase FakA is necessary for the incorporation of exogenous fatty acids into the lipid membrane. We previously demonstrated that the inactivation of fakA leads to decreased α-hemolysin (Hla) production but increased expression of the proteases SspAB
Nitin Agrawal et al.
Lab on a chip, 8(12), 2054-2061 (2008-11-22)
Neutrophil directional migration in response to chemical gradients, also known as chemotaxis, is one of the key phenomena in the immune responses against bacterial infection. To better study neutrophils chemotaxis, several in vitro assays have been developed that replicate chemotactic
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
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