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Merck

A6500

Acetylcholine bromide

≥99%

Synonyme(s) :

ACh

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About This Item

Formule linéaire :
(CH3)3N(Br)CH2CH2OCOCH3
Numéro CAS:
66-23-9
Poids moléculaire :
226.11
UNSPSC Code:
51151519
NACRES:
NA.25
PubChem Substance ID:
24891093
EC Number:
200-622-4
Beilstein/REAXYS Number:
3572117
MDL number:
MFCD00011814

Nom du produit

Acetylcholine bromide, ≥99%

InChI key

ZEHGKSPCAMLJDC-UHFFFAOYSA-M

InChI

1S/C7H16NO2.BrH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1

SMILES string

[Br-].CC(=O)OCC[N+](C)(C)C

assay

≥99%

form

powder

mp

140-143 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

Quality Level

100

Gene Information

human ... CHRM3(1131)

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Catégories apparentées

Application

Acetylcholine is an endogenous neurotransmitter at cholinergic synapses that amplifies action potential of the sarcolemma thereby inducing muscle contractions. Acetylcholine bromide is used as an acetylcholine receptor agonist to identify, characterize and differentiate among types of cholinergic receptors. Acetylcholine bromide is used as an inhibitor to identify and characterize natural and mutated butyrylcholinesterase(s).

Biochem/physiol Actions

Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
MKCV2188
MKCT0858
MKCP9464
MKCL2782
MKCJ0770

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Consulter la Bibliothèque de documents

Scott A Hollingsworth et al.
Nature communications, 10(1), 3289-3289 (2019-07-25)
Allosteric modulators are highly desirable as drugs, particularly for G-protein-coupled receptor (GPCR) targets, because allosteric drugs can achieve selectivity between closely related receptors. The mechanisms by which allosteric modulators achieve selectivity remain elusive, however, particularly given recent structures that reveal
James A Angus et al.
European journal of pharmacology, 804, 111-116 (2017-03-17)
Endothelin receptor antagonists are approved for pulmonary arterial hypertension. Development of selective ET Human isolated pulmonary (i.d. 5.5mm) and human radial (i.d. 3.23mm) artery ring segments were mounted in organ baths for isometric force measurement. Single concentration-contraction curves to endothelin-1
Lu Gan et al.
Acta pharmacologica Sinica, 37(12), 1555-1562 (2016-09-13)
Ginsenosides are considered to be the major pharmacologically active ginseng constituents, whereas 20(S)-protopanaxadiol [20(S)-PPD] is the active metabolite of ginsenosides in gut. In this study we investigated the effect of 20(S)-PPD on isolated rat thoracic aortas as well as its
Li-Yan Zhao et al.
Acta pharmacologica Sinica, 39(5), 875-884 (2018-03-30)
Xyloketal B (Xyl-B) is a novel marine compound isolated from mangrove fungus Xylaria sp. (No 2508). We previously showed that Xyl-B promoted endothelial NO release and protected against atherosclerosis through the Akt/eNOS pathway. Vascular NO production regulates vasoconstriction in central
Rahini Kakumanu et al.
Toxins, 11(4) (2019-04-04)
Russell's viper (Daboia russelii) venom causes a range of clinical effects in humans. Hypotension is an uncommon but severe complication of Russell's viper envenoming. The mechanism(s) responsible for this effect are unclear. In this study, we examined the cardiovascular effects
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