B0390
Bilirubin Oxidase from Myrothecium verrucaria
lyophilized powder, 15-65 units/mg protein
Synonyme(s) :
MvBOx, Bilirubin:oxygen oxidoreductase
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A propos de cet article
Numéro CAS:
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
Specific activity:
15-65 units/mg protein
Biological source:
fungus (Myrothecium verrucaria)
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Laissez-nous vous aiderbiological source
fungus (Myrothecium verrucaria)
Quality Level
form
lyophilized powder
specific activity
15-65 units/mg protein
composition
Protein, ≥15% biuret
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
greener alternative product characteristics
Waste Prevention
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.
sustainability
Greener Alternative Product
technique(s)
toxicology assay: suitable
greener alternative category
, Enabling
shipped in
dry ice
storage temp.
−20°C
Catégories apparentées
General description
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for energy efficiency and waste prevention when used in biofuel cell research. For more information see the article in biofiles.
Bilirubin oxidase (BOD) belongs to the subclass of the multicopper oxidase family. It is usually found in fungi.Bilirubin Oxidase is composed of three cupredoxin-like domains that result in two active sites formed by four copper ions. Research area: Apoptosis
Bilirubin oxidase (BOD) belongs to the subclass of the multicopper oxidase family. It is usually found in fungi.Bilirubin Oxidase is composed of three cupredoxin-like domains that result in two active sites formed by four copper ions. Research area: Apoptosis
Application
Bilirubin Oxidase from Myrothecium verrucaria has been used to eliminate the interference of bilirubin. It has also been used to chemically modify with fluorescein derivative (FS) and combined with multivariate calibration to analyse direct bilirubin (dBR) and total bilirubin (tBR).
Bilirubin oxidase is used to degrade bilirubin. Bilirubin oxidase, from Myrothecium verrucaria, may be used to determine free hemoglobin in icteric specimens . It also has potential application in dye effluent decolorization and is a potential treatment for neonatal jaundice.
Biochem/physiol Actions
Bilirubin oxidase (BOD) is a multicopper oxidase that catalyzes the oxidation of bilirubin to biliverdin. Oxygen is the electron acceptor and is reduced to water. The enzyme is used for diagnostic analysis of bilirubin in serum during medical examinations of the serum. It has also been used as an enzymatic catalyst for the cathode of biofuel cells that work under neutral conditions. It is a monomeric protein with a molecular mass of 60 kDa and high reactivity at neutral pH. BOD participates in porphyrin and chlorophyll metabolism.
Bilirubin oxidase (BOD) is capable of oxidizing laccase substrates.
Other Notes
One unit will oxidize 1.0 μmole of bilirubin per min at pH 8.4 at 37 °C.
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Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Classe de stockage
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Emmanuel Suraniti et al.
Analytical chemistry, 83(7), 2824-2828 (2011-03-17)
Immobilization and electrical wiring of enzymes is of particular importance for the elaboration of efficient biosensors and can be cumbersome. Here, we report a fast and easy protocol for enzyme immobilization, and as a proof of concept, we applied it
Dan Wen et al.
Analytical chemistry, 83(10), 3968-3972 (2011-04-19)
A self-powered electrochemical sensor has been facilely designed for sensitive detection of Hg(2+) based on the inhibition of biocatalysis process of enzymatic biofuel cell (BFC) for the first time. The as-prepared one-compartment BFC, which was consisted of alcohol dehydrogenase supported
James A Cracknell et al.
Dalton transactions (Cambridge, England : 2003), 40(25), 6668-6675 (2011-05-06)
The blue multi-copper oxidase bilirubin oxidase (BOx) from the ascomycete plant pathogen Myrothecium verrucaria (Mv) efficiently catalyses the oxidation of bilirubin to biliverdin, with the concomitant reduction of O(2) to water, a reaction of considerable interest for low-temperature bio-fuel cell
Bilirubin oxidase activity of Bacillus subtilis CotA
Sakasegawa S, et al.
Applied and Environmental Microbiology, 72(1), 972-975 (2006)
Masayo Iwaki et al.
FEBS letters, 584(18), 4027-4031 (2010-08-24)
Redox-induced protonation state changes of the Glu residue in the multicopper oxidases, CueO and bilirubin oxidase (BO), were studied by attenuated total reflectance-Fourier transform infrared spectroscopy. By monitoring IR bands of the carboxylic acid C=O stretch in the wild-type and
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