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C239

CNQX disodium salt hydrate

≥98% (HPLC), solid, AMPA/kainate receptor antagonist.

Synonyme(s) :

6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate

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A propos de cet article

Formule empirique (notation de Hill) :
C9H2N4Na2O4 · xH2O
Numéro CAS:
115066-14-3
Poids moléculaire :
276.12 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
24277972
NACRES:
NA.77
MDL number:
MFCD09953908
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
protect from light
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Nom du produit

CNQX disodium salt hydrate, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

orange to red

solubility

H2O: >2 mg/mL (warmed)

SMILES string

O.[Na+].[Na+].[O-]c1nc2cc(C#N)c(cc2nc1[O-])[N+]([O-])=O

InChI

1S/C9H4N4O4.2Na.H2O/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;;/h1-2H,(H,11,14)(H,12,15);;;1H2/q;2*+1;/p-2

InChI key

LCDWHGXMFAZHEO-UHFFFAOYSA-L

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)

Application

CNQX disodium salt hydrate has been used as:
  • as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
  • as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
  • as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)

Biochem/physiol Actions

Potent, competitive AMPA/kainate receptor antagonist.
CNQX(6-cyano-7-nitroquinoxaline-2,3-dioneis) is a potent, competitive AMPA/kainate receptor antagonist. It is a quinoxaline derivative and also an antagonist for non-N-methyl-d-aspartate (non-NMDA) glutamate receptor. CNQX mediates depolarization thalamic reticular nucleus via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs). It displays micromolar affinity towards AMPA/kainate receptor.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000513552
0000513553
0000513552
0000513553
0000446243

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Consulter la Bibliothèque de documents

Medicinal chemistry of competitive kainate receptor antagonists
Larsen, Ann M and Bunch, Lennart
ACS Chemical Neuroscience, 2(2), 60-74 (2010)
CNQX Blocks Kainate-induced Corneal Irritation
Ibitokun, Bernadette O and Miller, Kenneth E
investigate opthalmology and visual science, 53(14), 1855-1855 (2012)
Teri M Furlong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(14), 5012-5022 (2014-04-04)
Access to highly palatable and calorically dense foods contributes to increasing rates of obesity worldwide. Some have made the controversial argument that consumption of such foods can lead to "food addiction," yet little is known about how long-term access to
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