C3025
(±)-Chlorpheniramine maleate salt
≥99% (perchloric acid titration)
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A propos de cet article
Formule empirique (notation de Hill) :
C16H19ClN2 · C4H4O4
Numéro CAS:
Poids moléculaire :
390.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
204-037-5
MDL number:
Service technique
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Laissez-nous vous aiderQuality Level
assay
≥99% (perchloric acid titration)
form
powder
mp
130-135 °C (lit.)
originator
Bayer
SMILES string
CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O
InChI
1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key
DBAKFASWICGISY-BTJKTKAUSA-N
Gene Information
human ... HRH1(3269)
General description
Chlorpheniramine maleate (CPM)/(3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine is an alkylamine antihistamine.
Application
(±)-Chlorpheniramine maleate salt has been used:
- as H1 receptor antagonist to determine the receptor function
- to block the effect of compound 48/80 on plasma IGF-I
- as a standard for fast sensing and determination by sequential injector coupled with potentiometer
Biochem/physiol Actions
H1 Histamine receptor antagonist.
Chlorpheniramine maleate (CPM) can prevent rhinitis and urticaria. It is used to cure several allergic conditions. This antihistamine is used in small-animal veterinary practices.
Features and Benefits
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Endogenous histamine reduces plasma insulin-like growth factor I via H1 receptor-mediated pathway in the rat
Liao W, et al.
European Journal of Pharmacology, 374(3), 471-476 (1999)
Sensing of chlorpheniramine in pharmaceutical applications by sequential injector coupled with potentiometer
Saleh TA
Journal of Pharmaceutical Analysis, 1(4), 246-250 (2011)
Extracellular signal-regulated kinase (ERK) activation is required for itch sensation in the spinal cord
Zhang L, et al.
Molecular Brain, 7(1), 25-25 (2014)