C5424
Conduritol B epoxide
powder, ≥95% (TLC)
Synonyme(s) :
1,2-Anhydro-myo-inositol
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A propos de cet article
Numéro CAS:
UNSPSC Code:
12352119
PubChem Substance ID:
NACRES:
NA.32
MDL number:
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Conduritol B epoxide,
biological source
synthetic (organic)
Quality Level
assay
≥95% (TLC)
form
powder
solubility
water: 20 mg/mL, clear, colorless to faintly yellow
storage temp.
2-8°C
SMILES string
OC1C(O)C(O)C2OC2C1O
InChI
1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H
InChI key
ZHMWOVGZCINIHW-UHFFFAOYSA-N
General description
Conduritol B epoxide (CBE) is a mix of 1-L-1,2-anhydro-myo-inositol and 1-D-1,2-anhydro-myo-inositol.
Application
Conduritol B epoxide has been used as an inhibitor of GBA1 to discriminate between acid β-glucosidase (GBA1) and non-lysosomal β-glucosidase (GBA2) activity in β-glucosidase activity assay. It has also been used as a selective glucocerebrosidase (GCase) inhibitor.
Biochem/physiol Actions
Conduritol B epoxide (CBE) is capable of inactivating sucrase-isomaltase irreversibly. It can be used to produce cell and animal models to study on Gaucher disease (GD) and Parkinson′s disease (PD).
β-Glucosidase inhibitor
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling
Kuo CL, et al.
FEBS Journal, 286(3), 584-600 (2019)
Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity
Farfel-BT, et al.
Cell Reports, 28(1), 51-64 (2019)
Stereospecific ring opening of conduritol-B-epoxide by an active site aspartate residue of sucrase-isomaltase
Braun H, et al.
Biochimica et Biophysica Acta, 483(1), 135-140 (1977)