Accéder au contenu
Merck

Principaux documents

Voir toute la documentation

C7291

Clomipramine hydrochloride

≥98% (HPLC), powder

Synonyme(s) :

3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, Anafranil hydrochloride

Se connecter pour consulter les tarifs organisationnels et contractuels.

Sélectionner une taille de conditionnement

Changer de vue

A propos de cet article

Formule empirique (notation de Hill) :
C19H23ClN2 · HCl
Numéro CAS:
17321-77-6
Poids moléculaire :
351.31
NACRES:
NA.77
PubChem Substance ID:
24278087
UNSPSC Code:
12352116
EC Number:
241-344-3
MDL number:
MFCD00069234
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
200
Service technique
Besoin d'aide ? Notre équipe de scientifiques expérimentés est là pour vous.
Laissez-nous vous aider

Quality Level

200

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

H2O: 25 mg/mL, 0.1 M HCl: soluble

originator

Novartis

SMILES string

Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13

InChI

1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H

InChI key

WIMWMKZEIBHDTH-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A4(6532)

General description

Clomipramine hydrochloride is an antiobsessional drug. It has anticholinergic activity in vitro and in vivo. Clomipramine is used to treat obsessive compulsive disorder and panic disorder.

Application

Clomipramine hydrochloride has been used to manipulate serotonin (5-HT) mechanisms. It has also been used to study its role on bone mass.
Clomipramine hydrochloride has been used:
  • to study its effect on human serum albumin using UV-visible, fluorescence and circular dichroism (CD) techniques
  • to block itchy E3 ubiquitin protein ligase (ITCH) ubiquitin transthiolation
  • as a serotonin reuptake inhibitor
  • as a homologous to E6AP C terminus (HECT) E3 ligase inhibitor

Biochem/physiol Actions

Tricyclic antidepressant; inhibits serotonin and norepinephrine transporters.
Clomipramine hydrochloride (CLP) is a amphiphilic drug, with two benzene rings in its structure. It exhibits anti-depressant property by restoring the equilibrium of certain natural materials in the human being. CLP acts as a potential therapeutic for obsessive compulsive disorder.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Still not finding the right product?

Explore all of our products under

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1 - STOT SE 3

target_organs

Central nervous system, Central nervous system,Cardiovascular

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

ppe

dust mask type N95 (US), Eyeshields, Gloves

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
MKCQ6279
MKCJ8350
MKBV9663V
MKBS8660V
SLBD2368V

Vous ne trouvez pas la bonne version ?

Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Rechercher un(e) COA

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Genotoxic effect of the tricyclic antidepressant drug clomipramine hydrochloride in somatic and germ cells of male mice
El-Fiky SA, et al.
Asian Pacific Journal of Allergy and Immunology / Launched by the Allergy and Immunology Society of Thailand, 6(4), 321-327 (2016)
Novel therapeutic drug identification and gene correlation for fatty liver disease using high-content screening: Proof of concept
Luo Wei-Jia, et al.
European Journal of Pharmaceutical Sciences, 121, 106-117 (2018)
M Fujita et al.
European journal of nuclear medicine, 24(4), 403-408 (1997-04-01)
Many reports support the concept of serotonergic-dopaminergic interaction in the brain. However, at present, there are few methods to study this relationship in vivo. The purpose of this study was to investigate the effect of serotonin (5-HT) uptake inhibitor, clomipramine
Afficher tous les articles scientifiques apparentés