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Merck

C9301

Chicken Collagen Type II

from chicken sternal cartilage, powder, suitable for cell culture

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A propos de cet article

Numéro CAS:
9007-34-5
UNSPSC Code:
12352202
NACRES:
NA.75
EC Number:
232-697-4
MDL number:
MFCD00130825

Principaux documents

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Nom du produit

Collagen from chicken sternal cartilage, Type II (Miller), powder, BioReagent, suitable for cell culture

biological source

chicken (Sternal cartilage)

type

Type II (Miller)

product line

BioReagent

form

powder

packaging

glass bottle of 100 mg
poly bottle of 25 mg
glass bottle of 5 mg

concentration

60-80% (biuret)

technique(s)

cell culture | mammalian: suitable

surface coverage

6‑10 μg/cm2

solubility

acetic acid: 0.5-2.0 mg/mL (Dissolve for several hours at 2-8 °C, occasionally swirling.)

UniProt accession no.

P02460

binding specificity

Peptide Source: Fibrinogen

shipped in

wet ice

storage temp.

2-8°C

Quality Level

300

Gene Information

chicken ... COL2A1(395069)

Catégories apparentées

Application

Collagen from chicken sternal cartilage has been used:

  • in enzyme–linked immunosorbent assay (ELISA).
  • chondrocyte-mediated tissue production in vitro.
  • induction, treatment, and assessment of collagenα induced arthritis (CIA).
  • cell proliferation assay.
  • as a coating for cell culture surfaces.

Biochem/physiol Actions

Collagen breaks down metabolically in the body to release N-telopeptide, which is the N-terminus of collagen. There is also C-telopeptide, which is presumably the C-terminus. N-telopeptide is released in urine, and its detection in diagnostic tests is used to screen for osteoporosis.

Features and Benefits

This collagen has been tested in culture with mammalian cells to verify it is low in endotoxin content.

General description

Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.
Collagen is made of three polypeptide chains. Type 2 collagen is ubiquitously present in the hyaline cartilage. It is a homotrimer made of three α1 chains. Type 2 collagen is also predominant in nucleus pulposus of the vertebral disc and vitreous body of the eye. The proteoglycan obtained from the chicken sternal cartilage is similar to type nine collagen structure.

Other Notes

Major component of articular cartilage.

Preparation Note

Prepared by a modification of the method of Trentham, D.E., et al.

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000477752
0000477751
0000477751
0000477752
0000436117

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Consulter la Bibliothèque de documents

Mesenchymal-Epithelial Interactions in Neural Development (2013)
Biology of Proteoglycans (2013)
Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes.
Tsuchida A I, et al.
Arthritis Research & Therapy, 16(5), 441-441 (2014)
Blockade of the interleukin?7 receptor inhibits collagen?induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators.
Hartgring S A, et al.
Arthritis and Rheumatism, 62(9), 2716-2725 (2010)
Derivation of Chondrogenic Cells from Human Embryonic Stem Cells for Cartilage Tissue Engineering
Toh W S
Methods in Molecular Biology (2014)
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