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Merck

C9750

β-Carotene

synthetic, ≥93% (UV), powder

Synonyme(s) :

β,β-Carotene, Provitamin A

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A propos de cet article

Formule empirique (notation de Hill) :
C40H56
Numéro CAS:
Poids moléculaire :
536.87
UNSPSC Code:
12352205
NACRES:
NA.79
PubChem Substance ID:
EC Number:
230-636-6
Beilstein/REAXYS Number:
1917416
MDL number:
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InChI key

OENHQHLEOONYIE-JLTXGRSLSA-N

InChI

1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+

SMILES string

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C(C)(C)CCC1

biological source

synthetic

assay

≥93% (UV)

form

powder

potency

~1,600,000 units vitamin A per g

color

dark red to brown

mp

178-179 °C

solubility

hexane: 1.1 mg/mL, DMSO: 30 μg/mL

storage temp.

−20°C

Quality Level

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General description

Carotenoids are an important class of naturally occurring pigments found in fruits and vegetables. Among the carotenoids, β-carotene has the greatest provitamin A potential and functions to reduce the risk of cancer, cardiovascular diseases and macular degeneration. Low water solubility and poor chemical stability attributes to low absorption of β-carotene from food. β-carotene along with digestible lipids enriches its bio accessibility. Emulsions or nano emulsions encapsulates effectively delivers lipophilic β-carotene and increases its bioavailability. β-carotene has anti-oxidant potential and reduces noise induced hearing loss and progression of macular degeneration.

Application

β-carotene has been used:
  • to generate nano emulsions to evaluate their bioavailability potential
  • as a standard, for β-carotene evaluation in blood and skin samples using high performance liquid chromatography (HPLC),
  • as a dietary supplement of vitamin-A in young rats by HPLC
  • as a dietary supplement in mice to reduce hearing loss and hair cell damage

Biochem/physiol Actions

The most important of the provitamins A, β-carotene can be classified as an antioxidant due to its inhibition of radical initiated peroxidation in vitro. However, in vivo it appears to act either as an antioxidant or a prooxidant depending on cellular environment. It reduces the incidence of many cancers, but enhances lung cancer incidence in smokers.
The most important of the provitamins A.

Packaging

Packaged in serum vials.

Disclaimer

Purchase minimum quantity required. Discard one month after opening.

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

217.9 °F - closed cup

flash_point_c

103.3 °C - closed cup

ppe

Eyeshields, Gloves


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Consulter la Bibliothèque de documents

Effects of dietary brazilian palm oil (Mauritia flexuosa L.) on Cholesterol profile and Vitamin A and e status of rats
Aquino JD, et al.
Molecules (Basel), 20(5), 9054-9070 (2015)
Joamyr Victor Rossoni-Júnior et al.
Journal of clinical biochemistry and nutrition, 50(3), 177-183 (2012-05-11)
Annatto has been identified as carotenoids that have antioxidative effects. It is well known that one of the key elements in the development of diabetic complications is oxidative stress. The immune system is especially vulnerable to oxidative damage because many
Carotenoid accumulation and their antioxidant activity in spent laying hens as affected by polarity and feeding period
Lee CY, et al.
Asian-Australasian Journal of Animal Sciences, 23(6), 799-805 (2010)
N B R Colombo et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 48(9), 852-862 (2015-07-23)
The antioxidant effects of Caryocar brasiliense Camb, commonly known as the pequi fruit, have not been evaluated to determine their protective effects against oxidative damage in lung carcinogenesis. In the present study, we evaluated the role of pequi fruit against
Colleen G Le Prell et al.
Free radical biology & medicine, 42(9), 1454-1463 (2007-03-31)
Free radical formation in the cochlea plays a key role in the development of noise-induced hearing loss (NIHL). The amount, distribution, and time course of free radical formation have been defined, including a clinically significant formation of both reactive oxygen

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