D1515
Doxorubicine hydrochloride
98.0-102.0% (HPLC)
Synonyme(s) :
Adriamycine, DOX, Hydroxydaunorubicine hydrochloride
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A propos de cet article
Nom du produit
Doxorubicine hydrochloride, 98.0-102.0% (HPLC)
InChI key
MWWSFMDVAYGXBV-RUELKSSGSA-N
InChI
1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
SMILES string
Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
biological source
synthetic (organic)
assay
98.0-102.0% (HPLC)
form
powder
mp
216 °C (dec.) (lit.)
solubility
water: 50.0-52.0 mg/mL, clear, orange to red
antibiotic activity spectrum
viruses
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
Quality Level
Gene Information
human ... TOP2A(7153)
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Application
- Dans des tests de viabilité cellulaire.
- Dans un test au MTT (bromure de 3-(4,5-diméthylthiazol-2-yl)-2,5-diphényl tétrazolium).
- Comme médicament dans l′administration de médicament via des microparticules à base de polymère de PLGA.
- Pour développer des cellules HepG2 et K562 résistant à la doxorubicine (HepG2-DR, K562-DR).
Biochem/physiol Actions
Features and Benefits
- Antibiotique de grande qualité convenant à de nombreuses applications de recherche.
- Idéal pour la recherche en biologie cellulaire, en métabolomique et en biochimie.
General description
La doxorubicine provoque également la formation d'espèces réactives de l'oxygène (ERO), qui endommagent encore davantage l'ADN, les protéines et les membranes. Il présente une activité cytotoxique, antitumorale, anticancéreuse et antinéoplasique et est utilisé dans la recherche sur le cancer, en métabolomique, en biologie cellulaire et en biochimie.
Other Notes
Preparation Note
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
Classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
What is the excitation and emission wavelength for Product D1515, Doxorubicin hydrochloride?
Doxorubicin has excitation maximum at 470 nm and an emission maximum at 585 nm in ethanol.
What is the difference between Doxorubicin hydrochloride Products D1515 and D1317?
Product No. D1317, Doxorubicin hydrochloride solution has been discontinued and is no longer available. We now offer Product No. D1515 which is a powder.
How can I store a solution of Product D1515, Doxorubicin hydrochloride?
Aqueous solutions are unchanged after one month at 5 °C but unstable at higher temperatures or at either acid or alkaline pH. Several studies cite that stability is related to pH, exposure to light and the medium used for storage. Doxorubicin hydrochloride is subject to light degradation at <0.5 mg/mL, with considerable loss of bioactivity. If stored at 25 °C in the dark in 5% glucose, pH 4.7 (or 3.3% glucose + 0.3% sodium chloride, pH 4.4), solutions were stable (5% or less change) for at least 4 weeks.
What can be used to make a solution of Product D1515, Doxorubicin hydrochloride?
The solubility of doxorubicin is tested in water (50 mg/mL), yielding a clear orange to red solution.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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