D3168
Duramycin from Streptoverticillium cinnamoneus
≥90.0%
Synonyme(s) :
Duramycin, Lancovutide
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A propos de cet article
Formule empirique (notation de Hill) :
C89H125N23O25S3
Numéro CAS:
Poids moléculaire :
2013.28
UNSPSC Code:
51102829
NACRES:
NA.85
MDL number:
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≥90.0%
form
powder
solubility
0.1 M HCl: 10 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
protein synthesis | interferes
storage temp.
2-8°C
Quality Level
Catégories apparentées
General description
Chemical structure: tetracycline
Application
Duramycin is used to study chloride secretion by cardial, pancreatic and airway epithelial voltage-gated ion channels. It is used to study cystic fibrosis and as a novel phosphatidylethanolamine-binding molecular probe. It is used to stimulate sodium transport in cultured human colonic epithelia.
Biochem/physiol Actions
Duramycin is the smallest known polypeptide since it has only 19 amino acids. It has a defined 3-dimensional binding structure. Duramycin binds phosphatidylethanolamine (PtdE) at a 1:1 ratio with high affinity and exclusive specificity. It enhances chloride secretion in airway epithelium.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Andrei Marconescu et al.
Biochimica et biophysica acta, 1778(10), 2217-2224 (2008-06-24)
The major anionic phospholipid, phosphatidylserine (PS), and the neutral phospholipid, phosphatidylethanolamine (PE), are largely confined to the inner leaflet of the plasma membrane bilayer in mammalian cells under normal conditions. This asymmetry is lost when cells undergo apoptosis, become activated
M M Cloutier et al.
The American journal of physiology, 259(3 Pt 1), C450-C454 (1990-09-01)
The effect of duramycin, a polypeptide antibiotic, on Cl- transport in canine tracheal epithelium mounted in Ussing chambers was studied. Over a narrow concentration range, duramycin increased short-circuit current (Isc) and net Cl- secretion and had no effect on mannitol
Igor Oliynyk et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 118(12), 982-990 (2010-11-26)
The lantibiotic duramycin (Moli1901, Lancovutide) has been suggested as a drug of choice in the treatment for cystic fibrosis (CF). It has been proposed that duramycin may stimulate chloride secretion through Ca²(+) -activated Cl⁻ channels (CaCC). We investigated whether duramycin
K Sundquist
Bone and mineral, 20(1), 17-29 (1993-01-01)
Proton transport in microsomal vesicles derived from medullary bone of laying hens was observed to be inhibited in a dose-dependent manner with fusidic acid, 7-chloro-4-nitrobenz-2-oxa-1,3-diatzole (NBD-Cl), duramycin and dicyclohexylcarbodiimide (DCCD). The IC50 values were 570 microM, 4.5 microM, 10 micrograms/ml
Ilka Steiner et al.
Naunyn-Schmiedeberg's archives of pharmacology, 378(3), 323-333 (2008-05-27)
Duramycin (Moli1901) is being developed for the treatment of reduced mucociliary clearance in cystic fibrosis. This study was conducted to estimate lung residence time and systemic exposure and to assess whether duramycin causes an inflammatory response. Six volunteers were administered
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