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Merck

D3506

Sodium diethyldithiocarbamate trihydrate

≥97% (perchloric acid titration), chelating agent, powder or crystals

Synonyme(s) :

Cupral, Diethyldithiocarbamic acid sodium salt

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About This Item

Formule linéaire :
(C2H5)2NCSSNa · 3H2O
Numéro CAS:
20624-25-3
Poids moléculaire :
225.31
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
57654092
EC Number:
205-710-6
MDL number:
MFCD00150617
Beilstein/REAXYS Number:
3920507

Nom du produit

Sodium diethyldithiocarbamate trihydrate,

InChI key

WWGXHTXOZKVJDN-UHFFFAOYSA-M

InChI

1S/C5H11NS2.Na.3H2O/c1-3-6(4-2)5(7)8;;;;/h3-4H2,1-2H3,(H,7,8);;3*1H2/q;+1;;;/p-1

SMILES string

[H]O[H].[H]O[H].[H]O[H].CCN(CC)C(=S)S[Na]

vapor density

5.9 (vs air)

assay

≥97% (perchloric acid titration)

form

powder or crystals

mp

95-98.5 °C (lit.)

solubility

water: 1 g/10 mL, slightly hazy

storage temp.

room temp

Quality Level

200

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Catégories apparentées

Application

Spin trap used in conjunction with Fe2+ to detect NO in brain, kidney, liver, and other tissues.
Spin trap used in conjunction with Fe2+ to detect NO in brain, kidney, liver, and other tissues. Simultaneous direct measurement of NO* and pO2 has been reported. A copper chelator, it has been used to quantitate copper in biological materials by ESR and is an inhibitor of superoxide dismutase, ascorbate oxidase, and other enzymes.

Biochem/physiol Actions

Inhibits induction of macrophage nitric oxide synthase.

Disclaimer

May form insoluble oxidation products in storage. Sensitivity in colorimetric copper determination not usually affected.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Dopamine, Norepinephrine and Epinephrine Synthesis page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
BCCN2823
BCCL7232
BCCL4747
BCCK4771
BCCH4339

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Y Suzuki et al.
Free radical research, 28(3), 293-299 (1998-08-04)
To detect nitric oxide (NO) in the rat brain during lipopolysaccharide (LPS)-induced sepsis, electron paramagnetic resonance (EPR) was employed with the NO trapping technique, using an iron and N,N-diethyldithiocarbamate (DETC) complex. An X-band (about 9.5 GHz) EPR system detected a
Tianhui Liu et al.
British journal of pharmacology, 175(24), 4480-4495 (2018-09-29)
Diethyldithiocarbamate (DDC) is a major metabolite of disulfiram that is a potential drug for alcoholism treatment. In the present study, we attempted to explore the possible effect of DDC on non-alcoholic fatty liver disease (NAFLD) and related fibrosis in vivo.
Jonathan H Pérez et al.
The Journal of experimental biology, 223(Pt 1) (2019-12-05)
The hypothalamic-pituitary-adrenal (HPA) axis is under complex regulatory control at multiple levels. Enzymatic regulation plays an important role in both circulating levels of glucocorticoids and target tissue exposure. Three key enzyme pathways are responsible for the immediate control of glucocorticoids.
Muriel Cuendet et al.
Nature protocols, 1(4), 1915-1921 (2007-05-10)
The cyclooxygenase (COX) reaction can be monitored by measurement of oxygen consumption, peroxidase co-substrate oxidation or prostaglandin (PG) detection. This protocol describes a procedure measuring cyclooxygenase activity by quantifying PGE2 produced by enzymatic conversion of arachidonic acid, in the presence
Ji Youn Youn et al.
Redox biology, 46, 102099-102099 (2021-09-13)
The outbreak of COVID-19 has remained uncontained with urgent need for robust therapeutics. We have previously reported sex difference of COVID-19 for the first time indicating male predisposition. Males are more susceptible than females, and more often to develop into
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