D3900
Desipramine hydrochloride
≥98% (TLC), powder, imipramine metabolite
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A propos de cet article
Formule empirique (notation de Hill) :
C18H22N2 · HCl
Numéro CAS:
Poids moléculaire :
302.84
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
200-373-1
MDL number:
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Desipramine hydrochloride, ≥98% (TLC), powder
Quality Level
assay
≥98% (TLC)
form
powder
color
white to off-white
solubility
H2O: 50 mg/mL
originator
Sanofi Aventis
storage temp.
2-8°C
SMILES string
Cl[H].CNCCCN1c2ccccc2CCc3ccccc13
InChI
1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H
InChI key
XAEWZDYWZHIUCT-UHFFFAOYSA-N
Gene Information
human ... SLC6A2(6530)
General description
Desipramine, a metabolite of imipramine and iofepramine is an active tricyclic antidepressant.
Application
Desipramine hydrochloride has been used:
- to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons
- to protect unselective damage to the noradrenergic system
- as a norepinephrine re-uptake inhibitor to treat rats for lesioning
Biochem/physiol Actions
Desipramine is used to treat depression. It is also used to manage enuresis in children. Desipramine helps to eliminate the pain triggered by diabetic neuropathy.
Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (Ki = 4 nM) than the serotonin transporter (Ki = 61 nM).
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Disclaimer
Hygroscopic
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease
Tillerson J L, et al.
Neuroscience, 119(3), 899-911 (2003)
Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy
Max M B, et al.
The New England Journal of Medicine, 326(19), 1250-1256 (1992)
Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation
Li S, et al.
Journal of Neurophysiology (2007)