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D4628

Diethylstilbestrol

Name: Diethylstilbestrol
Brand: SIGMA

≥99% (HPLC), Synthetic estrogen, powder

Synonyme(s) :

(E)-3,4-bis(4-hydroxyphényl)-3-hexène

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A propos de cet article

Formule empirique (notation de Hill) :

C₁₈H₂₀O₂

Numéro CAS:

56-53-1

Poids moléculaire :

268.35

NACRES:

NA.77

PubChem Substance ID:

24893887

UNSPSC Code:

51111800

EC Number:

200-278-5

MDL number:

MFCD00002373

Beilstein/REAXYS Number:

2056095

Assay:

≥99% (HPLC)

Form:

powder

Quality level:

200

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Propriétés

Nom du produit

Diethylstilbestrol, ≥99% (HPLC)

Quality Level

200

assay

≥99% (HPLC)

form

powder

SMILES string

CC\C(c1ccc(O)cc1)=C(\CC)c2ccc(O)cc2

InChI

1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+

InChI key

RGLYKWWBQGJZGM-ISLYRVAYSA-N

Gene Information

human ... ESR1(2099), ESR2(2100), ESRRG(2104)
mouse ... Esr1(13982)
rat ... Ar(24208), Esr1(24890)

Description

Application

Diethylstilbestrol has been used:

to evaluate the estrogenic activity of diethylstilbestrol by quantitating the expression levels of endogenous estrogen-regulated marker genes
to evaluate the estrogenic, androgenic and toxicity responses in bioluminescent yeast bioreporter assay (BLYES)
to detect its effect on the proliferation and tyrosinase activity of melanocytes

Biochem/physiol Actions

Diethylstilbestrol is a synthetic estrogen with carcinogenic properties. Causes renal clear-cell carcinoma in Syrian hamster. In humans it causes increased risk of breast cancer, clear cell adenocarcinoma (CCA) of the vagina and cervix, and reproductive anomalies. Used in the treatment of prostate cancer to block the production of testosterone.