D7693
Dynasore monohydrate
≥97.5% (HPLC), powder, dynamin 1 and dynamin 2 GTPase activity inhibitor
Synonyme(s) :
3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide monohydrate
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A propos de cet article
Nom du produit
Dynasore monohydrate,
SMILES string
O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O
InChI key
FKWZHQSDBMSHTN-ZIOFAICLSA-N
InChI
1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;
form
powder
storage condition
protect from light
color
off-white
solubility
DMSO: ≥10 mg/mL
H2O: insoluble
storage temp.
−20°C
Quality Level
Catégories apparentées
Application
- for priming fetal mesenchymal stem/stromal cells (fMSC)
- in confocal microscopy
- in wound healing/scratch and tube-formation assay
- to analyse its effects on Coxsackievirus A9 (CAV9) infection
- to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis
- in live imaging of cells
Biochem/physiol Actions
Features and Benefits
General description
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.
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Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
How can I store a solution of Product D7693, Dynasore hydrate?
We do not test solution stability for this product. In general, drug solutions are best prepared immediately before use. We recommend storing at -20°C in single use aliquots.
What can I use to make a solution of Product D7693, Dynasore hydrate?
As listed on the product page on the website, Dynasore is soluble in DMSO at 10 mg/mL. It is also soluble in ethanol at 1 mg/mL.
What concentration of Product D7693, Dynasore hydrate, should I use in my experiment?
The following reference uses Dynasore at 80 μM: Massol, R.H., et al., A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating. Proc. Nat. Acad. Sci., USA, 103, 10265-10270 (2006).
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