D7693
Dynasore monohydrate
≥97.5% (HPLC), powder, dynamin 1 and dynamin 2 GTPase activity inhibitor
Synonyme(s) :
3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide monohydrate
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A propos de cet article
Formule empirique (notation de Hill) :
C18H14N2O4 · xH2O
Numéro CAS:
Poids moléculaire :
322.31 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Laissez-nous vous aiderNom du produit
Dynasore monohydrate,
SMILES string
O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O
InChI key
FKWZHQSDBMSHTN-ZIOFAICLSA-N
InChI
1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;
form
powder
storage condition
protect from light
color
off-white
solubility
DMSO: ≥10 mg/mL, H2O: insoluble
storage temp.
−20°C
Quality Level
Catégories apparentées
General description
Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.
Application
Dynasore hydrate has been used:
- for priming fetal mesenchymal stem/stromal cells (fMSC)
- in confocal microscopy
- in wound healing/scratch and tube-formation assay
- to analyse its effects on Coxsackievirus A9 (CAV9) infection
- to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis
- in live imaging of cells
Biochem/physiol Actions
Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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Phosphatidylinositol 3-kinase class II alpha-isoform PI3K-C2alpha is required for transforming growth factor beta-induced Smad signaling in endothelial cells
Aki S, et al.
The Journal of Biological Chemistry, jbc-M114 (2015)
Intracellular trafficking and endocytosis of CXCR4 in fetal mesenchymal stem/stromal cells
Pelekanos RA, et al.
BMC Cell Biology, 15(1), 15-15 (2014)
Dynasore-not just a dynamin inhibitor
Preta G, et al.
Cell communication and signaling : CCS, 13(1), 24-24 (2015)
Florian Ehlgen et al.
PloS one, 7(6), e38781-e38781 (2012-06-22)
Haemoglobin degradation during the erythrocytic life stages is the major function of the food vacuole (FV) of Plasmodium falciparum and the target of several anti-malarial drugs that interfere with this metabolic pathway, killing the parasite. Two multi-spanning food vacuole membrane
Radioimmunotherapy of fibroblast activation protein positive tumors by rapidly internalizing antibodies
Fischer E, et al
Clinical Cancer Research, clincanres-clinca0644 (2012)
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