D8783
7-Déaza-2′-déoxyguanosine 5′-triphosphate lithium salt
10 mM in H2O
Synonyme(s) :
−N7-dGTP, 7-Déaza-dGTP
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A propos de cet article
Formule empirique (notation de Hill) :
C11H17N4O13P3
Numéro CAS:
Poids moléculaire :
506.19
NACRES:
NA.52
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Assay:
≥95% (HPLC)
Biological source:
Porcine muscle, rabbit muscle
Form:
liquid
Storage temp.:
−20°C
Service technique
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Laissez-nous vous aiderQuality Level
biological source
Porcine muscle, rabbit muscle
assay
≥95% (HPLC)
form
liquid
feature
PCR Additives
concentration
10 mM in H2O
technique(s)
PCR: suitable
color
colorless
shipped in
dry ice
storage temp.
−20°C
SMILES string
NC1=NC(=O)c2ccn(C3CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O3)c2N1
InChI
1S/C11H17N4O13P3/c12-11-13-9-5(10(17)14-11)1-2-15(9)8-3-6(16)7(26-8)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,6-8,16H,3-4H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,12,13,14,17)
InChI key
DLLXAZJTLIUPAI-UHFFFAOYSA-N
Application
7-Deaza-2′-deoxyguanosine 5′-triphosphate lithium salt has been used as a lysis agent to evaluate its efficiency on direct cell lysis, RNA stability, and compatibility with downstream reverse transcription quantitative real-time PCR during the analyzes of samples with small numbers of cells.
Biochem/physiol Actions
7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-deaza-dGTP) competes with natural substrate dGTP and blocks the telomerase activity. This nucleotide once incorporated into the telomere alters the secondary structure of the telomere making it difficult for telomerase to identify it for further telomere synthesis. This dGTP analog pairs weakly with conventional bases to minimize DNA secondary structures, while being a good substrate for DNA polymerases. 7-deaza-dGTP in combination with dimethyl sulfoxide (DMSO) and betaine enhances the polymerase chain reaction (PCR) amplification of GC-rich DNA sequences.
Classe de stockage
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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