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Merck

F1553

S-(+)-Fluoxetine hydrochloride

≥98% (HPLC), serotonin reuptake inhibitor, solid

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About This Item

Formule empirique (notation de Hill) :
C17H18NOF3 · HCl
Numéro CAS:
114247-06-2
Poids moléculaire :
345.79
UNSPSC Code:
12352200
PubChem Substance ID:
24278432
NACRES:
NA.77
MDL number:
MFCD04040001

Nom du produit

S-(+)-Fluoxetine hydrochloride, ≥98% (HPLC), solid

SMILES string

Cl.CNCC[C@H](Oc1ccc(cc1)C(F)(F)F)c2ccccc2

InChI key

GIYXAJPCNFJEHY-NTISSMGPSA-N

InChI

1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H/t16-;/m0./s1

assay

≥98% (HPLC)

form

solid

optical activity

[α]/D +14 to +19°, c = 1 in chloroform-d

storage condition

desiccated

color

white

solubility

H2O: soluble ≥20 mg/mL

originator

Eli Lilly

storage temp.

room temp

Quality Level

100

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

Catégories apparentées

Biochem/physiol Actions

Fluoxetine hcl (hydrochloride) is a selective serotonin reuptake inhibitor and functions as an antidepressant. This drug works at presynaptic terminals where it prevents the reuptake of serotonin, resulting in the accumulation of serotonin in extracellular fluid at synapses.
Selective serotonin reuptake inhibitor.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Fluoxetine hydrochloride or fluoxetine hcl is a psychotropic agent and one of the initial members of the anti-depressant class of drugs known as selective serotonin-reuptake inhibitors (SSRIs). It is the active ingredient of Prozac®.

Legal Information

Prozac is a registered trademark of Eli Lilly and Co.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
0000472615
0000472613
0000472613
0000472615
0000405739

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

S Hasebe et al.
British journal of pharmacology, 174(4), 314-327 (2016-12-18)
Prefrontal dopamine release by the combined activation of 5-HT Male mice were treated with picrotoxin to decrease GABA Picrotoxin caused an anxiogenic effect on three behavioural tests, but it did not affect the immobility time in the forced swim test.
Xin-Xian Ye et al.
Nuclear medicine and biology, 31(5), 557-562 (2004-06-29)
A radiopharmaceutical, (123)I-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine ([(123)I]ADAM), has been developed recently for evaluation of how serotonin transporters (SERT) function in the brain. However, the detailed biodistribution and specific binding in certain brain areas are not well investigated. In this study, both phosphor
David T Wong et al.
Nature reviews. Drug discovery, 4(9), 764-774 (2005-08-27)
In the early 1970s, evidence of the role of serotonin (5-hydroxytryptamine or 5-HT) in depression began to emerge and the hypothesis that enhancing 5-HT neurotransmission would be a viable mechanism to mediate antidepressant response was put forward. On the basis
Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the

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