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F9427

Fexofenadine hydrochloride

Name: Fexofenadine hydrochloride
Brand: SIGMA

>98% (HPLC), H1 histamine receptor antagonist, powder

Synonyme(s) :

Fexofenidine hydrochloride, MDL 16455 hydrochloride, Terfenidine carboxylate hydrochloride

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A propos de cet article

Formule empirique (notation de Hill) :

C₃₂H₃₉NO₄ · HCl

Numéro CAS:

153439-40-8

Poids moléculaire :

538.12

UNSPSC Code:

12352200

PubChem Substance ID:

24278447

NACRES:

NA.77

MDL number:

MFCD00865710

Assay:

>98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Propriétés

Nom du produit

Fexofenadine hydrochloride, >98% (HPLC)

Quality Level

100

assay

>98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: soluble ≥5 mg/mL

originator

Sanofi Aventis

storage temp.

−20°C

SMILES string

Cl[H].CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4

InChI

1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27;/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36);1H

InChI key

RRJFVPUCXDGFJB-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

Description

Application

Fexofenadine hydrochloride has been used as a non-cationic ampliphilic antihistamines in NCI-H661 cells and as a histamine H1 receptor antagonist in mice

Biochem/physiol Actions

Fexofenadine is used in treating allergic rhinitis and chronic idiopathic urticaria. It may give relief in bothersome symptom and is a second-generation antihistamines. Fexofenadine provides better relief compared to other antihistamines for nasal congestion. It is the active metabolite of terfenadine and bring down allergen-induced symptoms.

Fexofenadine is a non-sedating H1 histamine receptor antagonist.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Effect of the second-generation antihistamine, fexofenadine, on cough reflex sensitivity and pulmonary function

Dicpinigaitis PV and Gayle YE

British Journal of Clinical Pharmacology, 56(5), 501-504 (2003)

Pharmacokinetics of fexofenadine: evaluation of a microdose and assessment of absolute oral bioavailability

Lappin G, et al.

European Journal of Pharmaceutical Sciences, 40(2), 125-131 (2010)

The determination of crystal structures of active pharmaceutical ingredients from X-ray powder diffraction data: a brief, practical introduction, with fexofenadine hydrochloride as example.

Jürgen Brüning et al.

The Journal of pharmacy and pharmacology, 67(6), 773-781 (2015-02-14)

This study describes the general method for the determination of the crystal structures of active pharmaceutical ingredients (API) from powder diffraction data and demonstrates its use to determine the hitherto unknown crystal structure of fexofenadine hydrochloride, a third-generation antihistamine drug.

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