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Adenosine 5′-triphosphate (ATP) disodium salt hydrate

≥90%, bacterial (Corynebacterium sp), lyophilized powder

Synonyme(s) :

ATP disodium hydrate

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A propos de cet article

Formule linéaire :
C10H14N5O13P3Na2 · xH2O
Numéro CAS:
34369-07-8
Poids moléculaire :
551.14 (anhydrous basis)
eCl@ss:
32160414
PubChem Substance ID:
24895005
NACRES:
NA.26
EC Number:
213-579-1
MDL number:
MFCD00150755
UNSPSC Code:
12352208

Principaux documents

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Nom du produit

Adenosine 5′-triphosphate (ATP) disodium salt hydrate, vial of ~1 mg ATP

SMILES string

Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

InChI key

NTBQNWBHIXNPRU-MSQVLRTGSA-L

biological source

bacterial (Corynebacterium sp)

assay

≥90%

form

lyophilized powder

packaging

vial of ~1 mg ATP

solubility

water: soluble, clear, colorless (1 vial + 0.1 mL)

storage temp.

−20°C

Quality Level

200

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Catégories apparentées

Application

Adenosine 5′-triphosphate (ATP) disodium salt hydrate has been:
  • used as a standard to measure ATP by bioluminescence method
  • used in kinase buffer to assess the interaction between death-associated protein kinases (DAPK2) and 14-3-3-β
  • used as a standard in ATP colorimetric assay

Biochem/physiol Actions

Adenosine 5′-triphosphate (ATP) is one of the nucleoside triphosphate present in living system. It controls various biologic processes such as glucose metabolism, muscle contraction and neurotransmission. Apart from this, ATP serves as an important energy source for the cell. Administration of ATP might be useful in the treatment of non-small-cell lung cancer.
Adenosine 5′-triphosphate was shown to have inhibitory effects on the inflammatory response by abrogating secretion of TNF-α and promoting secretion of Interleukin-10.
P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems

Preparation Note

Each vial contains ~1.2 mg of Na2ATP • 3H2O equivalent to ~1.0 mg of ATP (2.0 μmol). Actual amount printed on the label.
Prepared to be substantially vanadium-free.

Classe de stockage

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000492797
0000392019
0000492797
0000324721
0000392019

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia--ischemia
Chavez-Valdez R, et al.
Neuroscience, 219, 192-203 (2012)
Els L R Swennen et al.
European journal of immunology, 35(3), 852-858 (2005-02-19)
In vitro studies suggest that extracellular nucleotides and nucleosides may be important regulators of inflammatory and immune responses. Most studies with adenosine 5'-triphosphate (ATP) have been performed in cell lines, which are remote from the human situation. The purpose of
Shay Eliahu et al.
Journal of medicinal chemistry, 53(24), 8485-8497 (2010-11-26)
Nucleotide pyrophosphatase/phosphodiesterases (NPPs) hydrolyze extracellular nucleotides and dinucleotides and thus control purinergic signaling. Enhanced NPP activity is implicated in health disorders such as osteoarthritis and cancer. We designed novel diadenosine polyphosphonate derivatives as potential NPP inhibitors. Analogues 1-4 bear a
Andrei A Ivanov et al.
Journal of medicinal chemistry, 50(6), 1166-1176 (2007-02-17)
A rhodopsin-based homology model of the nucleotide-activated human P2Y2 receptor, including loops, termini, and phospholipids, was optimized with the Monte Carlo multiple minimum conformational search routine. Docked uridine 5'-triphosphate (UTP) formed a nucleobase pi-pi complex with conserved Phe3.32. Selectivity-enhancing 2'-amino-2'-deoxy
Jie Ge et al.
Journal of medicinal chemistry, 49(15), 4606-4615 (2006-07-21)
17-Allylamino-17-demethoxygeldanamycin (17-AAG)1 is a semisynthetic inhibitor of the 90 kDa heat shock protein (Hsp90) currently in clinical trials for the treatment of cancer. However, 17-AAG faces challenging formulation issues due to its poor solubility. Here we report the synthesis and
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