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Merck

G2879

Glycine hydrochloride

≥99% (HPLC), NMDA receptors regulator, powder

Synonyme(s) :

Aminoacetic acid hydrochloride, Glycine HCl, Glycocoll hydrochloride, Aminoacetic acid, Aminoethanoic acid, Glycocoll

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A propos de cet article

Formule linéaire :
H2NCH2CO2H · HCl
Numéro CAS:
6000-43-7
Poids moléculaire :
111.53
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24895108
NACRES:
NA.32
EC Number:
227-841-8
MDL number:
MFCD00012872

Principaux documents

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Nom du produit

Glycine hydrochloride, ≥99% (HPLC)

SMILES string

Cl.NCC(O)=O

InChI

1S/C2H5NO2.ClH/c3-1-2(4)5;/h1,3H2,(H,4,5);1H

InChI key

IVLXQGJVBGMLRR-UHFFFAOYSA-N

assay

≥99% (HPLC)

form

powder

mol wt

111.53

storage condition

(Tightly closed Dry)

concentration

≤100%

technique(s)

immunohistochemistry: suitable

mp

176-180 °C (lit.)

solubility

water: 0.5 g/mL, clear, colorless

storage temp.

room temp

Quality Level

300

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Catégories apparentées

Application

Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues.
Glycine hydrochloride has been used:
  • in the preparation of glycine-HCl buffer
  • to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies
  • to regenerate the sensor to elute the bound C-reactive protein (CRP)

Biochem/physiol Actions

Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain.
Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group. Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane. It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices. Free glycine may have a protecting role in tissues against ischemia, hypoxia, and reperfusion.Glycine has been studied as a potential treatment for sepsis, arthritis, adult respiratory distress syndrome, and other inflammatory diseases.
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

General description

Research area: Neuroscience

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1

Classe de stockage

8A - Combustible corrosive hazardous materials

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000525387
0000525393
0000525388
0000525391
0000525391

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

M D Wheeler et al.
Cellular and molecular life sciences : CMLS, 56(9-10), 843-856 (2001-02-24)
The mechanism of the immunosuppressive effects of glycine and its pathophysiological applications are discussed in this review. Glycine has been well characterized in spinal cord as an inhibitory neurotransmitter which activates a glycine-gated chloride channel (GlyR) expressed in postsynaptic membranes.
Zipei Feng et al.
Journal of immunology (Baltimore, Md. : 1950), 196(9), 3943-3950 (2016-03-20)
Recent advances in multiplex immunohistochemistry techniques allow for quantitative, spatial identification of multiple immune parameters for enhanced diagnostic and prognostic insight. However, applying such techniques to murine fixed tissues, particularly sensitive epitopes, such as CD4, CD8α, and CD19, has been
Glycine
Hall JC
JPEN. Journal of parenteral and enteral nutrition, 22(6), 393-398 (2019)
Hydrolysis of organic phosphates by commercially available phytases: Biocatalytic potentials and effects of ions on their enzymatic activities
Tazisong IA, et al.
Journal of food, agriculture & environment, 6(3&4), 500-505 (2008)
A comparative study on the chitosan membranes prepared from glycine hydrochloride and acetic acid
Ma B, et al.
Carbohydrate Polymers, 91(2), 477-482 (2013)
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Contenu apparenté

Product Information Sheet - G2879

Product Information Sheet

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