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G9020

Gastrin I human

≥95% (HPLC), powder

Synonyme(s) :

Gastrin I, heptadecapeptide, HG-17, Little gastrin I, human, [18-Pyroglutamic acid]big gastrin I-(18-34)-peptide amide, human, [pGlu18]-Big gastrin I fragment 18-34 amide

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A propos de cet article

Formule empirique (notation de Hill) :
C97H124N20O31S
Numéro CAS:
Poids moléculaire :
2098.20
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
233-157-0
MDL number:
Service technique
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biological source

human

Quality Level

assay

≥95% (HPLC)

form

powder

mol wt

2098.20

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

concentration

≤100%

technique(s)

protein expression: suitable

solubility

water: 1.00-1.04 mg/mL, clear, colorless

UniProt accession no.

storage temp.

−20°C

SMILES string

CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@@H]6CCCN6C(=O)CNC(=O)[C@@H]7CCC(=O)N7)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc8ccccc8)C(N)=O

InChI

1S/C97H124N20O31S/c1-49(2)39-68(114-95(146)71(43-54-46-100-59-18-11-9-16-57(54)59)116-97(148)73-19-12-37-117(73)76(121)48-102-85(136)60-24-30-74(119)104-60)93(144)110-65(29-35-81(130)131)91(142)109-64(28-34-80(128)129)90(141)108-63(27-33-79(126)127)89(140)107-62(26-32-78(124)125)88(139)106-61(25-31-77(122)123)87(138)103-50(3)84(135)113-69(41-52-20-22-55(118)23-21-52)86(137)101-47-75(120)105-70(42-53-45-99-58-17-10-8-15-56(53)58)94(145)111-66(36-38-149-4)92(143)115-72(44-82(132)133)96(147)112-67(83(98)134)40-51-13-6-5-7-14-51/h5-11,13-18,20-23,45-46,49-50,60-73,99-100,118H,12,19,24-44,47-48H2,1-4H3,(H2,98,134)(H,101,137)(H,102,136)(H,103,138)(H,104,119)(H,105,120)(H,106,139)(H,107,140)(H,108,141)(H,109,142)(H,110,144)(H,111,145)(H,112,147)(H,113,135)(H,114,146)(H,115,143)(H,116,148)(H,122,123)(H,124,125)(H,126,127)(H,128,129)(H,130,131)(H,132,133)/t50-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-/m0/s1

InChI key

GKDWRERMBNGKCZ-RNXBIMIWSA-N

Gene Information

human ... GAST(2520)

General description

Research area: Cell Signaling

The GAST gene is mapped to human chromosome 17q21. Gastrin is a linear peptide. It is a gastrointestinal hormone, produced by G cells in the stomach.

Application

Gastrin I human has been used:
  • to treat AGS stably transfected with gastrin receptor/cholecystokinin receptor 2 (CCK2R) (AGS-GR) cells to study the expression and secretion of clusterin (CLU) in human gastric cancer cells
  • as a component of growth medium for culturing mouse normal esophageal epithelial organoid (mNEEO)
  • as a supplement in basal culture media to use for organoid-like cultures
  • as a molecular weight marker to calibrate superdex® 30 columns.

Biochem/physiol Actions

Gastrin plays a major role in parietal cell function, gastric epithelial cell multiplication, and differentiation. It acts as a modulator in maintaining and organizing gastric mucosa. It is produced in the stomach and stimulates gastric acid secretion. Gastrin is an important growth factor for the gastrointestinal tract. Gastrin binds with high affinity to the cholecystokinin B receptor (CCKBR) that belongs to the family of G-protein coupled receptors. It induces islet differentiation in the pancreas.

Other Notes

Lyophilized from 0.1% TFA in H2O

Legal Information

Superdex is a registered trademark of Cytiva


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Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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M Y Chowers et al.
Gastroenterology, 117(5), 1113-1118 (1999-10-27)
Helicobacter pylori resides within the gastric mucosa, a niche hostile to other microorganisms. Human gastrin levels are elevated after infection and return to normal after eradication. The aim of this study was to test the direct effect of gastrin on
C Saillan-Barreau et al.
Diabetes, 48(10), 2015-2021 (1999-10-08)
Gastrin (G) and cholecystokinin (CCK) are gastrointestinal neuropeptides that are released into circulation during a meal. G is also transiently expressed during embryogenic and early ontogenic development of the pancreas and is believed to act on islet-cell development. Both peptides
Physiology of cholangiocytes
Physiology of the Gastrointestinal Tract (2012)