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Merck

G9910

Sodium glycodeoxycholate

BioXtra, ≥97% (HPLC)

Synonyme(s) :

3α,12α-Dihydroxy-5β-cholan-24-oic acid N-(carboxymethyl)amide, Glycodeoxycholic acid sodium salt, Glycodesoxycholic acid, N-(3α,12α-Dihydroxy-24-oxocholan-24-yl)glycine

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A propos de cet article

Formule empirique (notation de Hill) :
C26H42NNaO5
Numéro CAS:
16409-34-0
Poids moléculaire :
471.61
NACRES:
NA.25
PubChem Substance ID:
24895386
UNSPSC Code:
12161900
EC Number:
240-455-4
MDL number:
MFCD00036742

Principaux documents

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InChI key

BMYWWGPEKRLDGW-ZXMGEDLUSA-N

InChI

1S/C26H43NO5.Na.H/c1-15(4-9-23(30)27-14-24(31)32)19-7-8-20-18-6-5-16-12-17(28)10-11-25(16,2)21(18)13-22(29)26(19,20)3;;/h15-22,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);;/t15-,16-,17-,18+,19-,20+,21+,22+,25+,26-;;/m1../s1

SMILES string

[Na].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(=O)NCC(O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

description

anionic

product line

BioXtra

assay

≥97% (HPLC)

mol wt

471.61 g/mol

impurities

≤0.0025% Phosphorus (P), ≤0.1% Insoluble matter

CMC

2.1 mM

solubility

H2O: 0.1 M, clear to slightly hazy, colorless to almost colorless

anion traces

chloride (Cl-): ≤1%, sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%, Ca: ≤0.011%, Cu: ≤0.0005%, Fe: ≤0.001%, K: ≤0.005%, NH4+: ≤0.05%, Pb: ≤0.001%, Zn: ≤0.003%

Quality Level

200

General description

Sodium glycodeoxycholate is a bile salt that can be used to form biomimicking environments.

Application

Sodium glycodeoxycholate has been used in a study to develop more similar mimetic intestinal fluids to physiological fluids than those developed by mixed bile salt systems (MBS). It has also been used in a study to investigate Ca2+ buffering capability of bile salt micelles.

Biochem/physiol Actions

Induces apoptosis in hepatocytes; may induce DNA cleavage.

Other Notes

Bile Salt

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
BCCN4029
BCCG6083
BCCG0654
BCCC1463
BCBZ2950

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Bile salt composition is secondary to bile salt concentration in determining hydrocortisone and progesterone solubility in intestinal mimetic fluids
Huda H Zughaid, et al.
International Journal of Pharmaceutics, 422, 7-7 (2012)
Raina Thakur et al.
Photochemistry and photobiology, 88(5), 1248-1255 (2012-05-23)
Photophysical properties of two widely used antibiotic fluoroquinolone drugs, namely Norfloxacin (NOR) and Ofloxacin (OFL) have been investigated in biomimicking environments formed by bile salts. Experimental results demonstrate that photophysical enhancement and fall of a particular prototropic species are sensitive
Elisabetta De Angelis et al.
Food & function, 8(4), 1599-1610 (2017-03-16)
Soy is an important component of the human diet thanks to its nutritional value and high protein content; however, it also represents a risk for allergenic consumers due to its potential to trigger adverse reactions in sensitized individuals. The putative
Domenico Trombetta et al.
Nutrients, 12(11) (2020-11-11)
Almond kernels contain phytochemicals with positive health effects in relation to heart disease, diabetes and obesity. Several studies have previously highlighted that almond cell wall encapsulation during digestion and particle size are factors associated with these benefits. In the present
Hu-He Chen et al.
Guang pu xue yu guang pu fen xi = Guang pu, 30(3), 748-752 (2010-05-26)
In the present article, NaGDC was used to study the Ca(2+)-buffering capability of bile salt micelles. NaGDC is a naturally occurring bile salt which constitutes approximately 10 molar percent of bile salt composition in gallbladder. The authors selected glycine conjugated
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