H0888

Hydrocortisone

Name: Hydrocortisone
Brand: SIGMA

BioReagent, suitable for cell culture

Synonyme(s) :

11β,17α,21-trihydroxypregn-4-ène-3,20-dione, 4-pregnène-11β,17α,21-triol-3,20-dione, Composé F de Kendall, Substance M de Reichstein

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About This Item

Formule empirique (notation de Hill) :

C₂₁H₃₀O₅

Numéro CAS:

50-23-7

Poids moléculaire :

362.46

UNSPSC Code:

12352209

NACRES:

NA.77

PubChem Substance ID:

24895415

EC Number:

200-020-1

Beilstein/REAXYS Number:

1354819

MDL number:

MFCD00011654

biological source:

soybean

form:

powder

assay:

≥98%

Nom du produit

Hydrocortisone, BioReagent, suitable for cell culture

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

biological source

soybean

product line

BioReagent

assay

≥98%

form

powder

technique(s)

cell culture | mammalian: suitable

mp

211-214 °C (lit.)

solubility

chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to very faintly yellow

shipped in

ambient

storage temp.

room temp

Quality Level

200

Gene Information

human ... ABCB1(5243), CYP3A4(1576), NR3C1(2908), SERPINA6(866)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126)
rat ... Ar(24208), Nr3c1(24413)

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Biochem/physiol Actions

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na²⁺ retention potency.

Principal glucocorticoïde secrété par la glande cortico-surrénale.

Hydrocortisone (also referred to as cortisol) is an endogenous glucocorticoid which is secreted by the adrenal gland. It is produced from the hypothalamus–pituitary–adrenal (HPA) axis. Hydrocortisone interacts with glucocorticoid receptors and regulates various signaling pathways. It is associated with the induction of energy mobilization, increase in cerebral perfusion rates and local glucose consumption. It is also linked with increase in cardiovascular output and respiration, redistribution of blood, delivery of molecules and energy to the brain and muscles and modulation of immune responses.

Application

Hydrocortisone has been used as a supplement in culture media for oligodendrocytes, colon cells and epithelial cells.

Physical form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Preparation Note

To prepare 50 μg/mL stock solution, add 1.0 mL absolute ethanol to 1.0 mg of product, gently swirl to dissolve, add 19 mL sterile medium.

pictograms

GHS08

signalword

Danger

hcodes

H360Df,H373

pcodes

P202 - P260 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1A - STOT RE 2

target_organs

Adrenal gland,Bone marrow

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificats d'analyse (COA)

Lot/Batch Number

0000453896

0000490374

0000453895

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Immunomodulation in septic shock: hydrocortisone differentially regulates cytokine responses.

Briegel J et al.

Journal of the American Society of Nephrology, 12, S70-S70 (2001)

The cortisol awakening response (CAR): facts and future directions.

Fries E et al.

International Journal of Psychophysiology, 72, 67-67 (2009)

Human colon tissue in organ culture: preservation of normal and neoplastic characteristics.

Dame MK et al.

In Vitro Cellular & Developmental Biology. Animal, 46, 114-114 (2010)

Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity.

Marc Hafner et al.

Cell chemical biology, 26(8), 1067-1080 (2019-06-11)

The target profiles of many drugs are established early in their development and are not systematically revisited at the time of FDA approval. Thus, it is often unclear whether therapeutics with the same nominal targets but different chemical structures are

The microstructure of laminin-111 compensates for dystroglycan loss in mammary epithelial cells in downstream expression of milk proteins.

A J Kent et al.

Biomaterials, 218, 119337-119337 (2019-07-22)

Laminin-111 (Ln-1), an extracellular matrix (ECM) glycoprotein found in the basement membrane of mammary gland epithelia, is essential for lactation. In mammary epithelial cells (MECs), dystroglycan (Dg) is believed to be necessary for polymerization of laminin-111 into networks., thus we

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