H2775
DL-threo-β-Hydroxyaspartic acid
Synonyme(s) :
threo-2-Amino-3-hydroxysuccinic acid
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A propos de cet article
Formule empirique (notation de Hill) :
C4H7NO5
Numéro CAS:
Poids moléculaire :
149.10
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352106
NACRES:
NA.32
EC Number:
224-299-4
MDL number:
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storage temp.
−20°C
SMILES string
N[C@H]([C@@H](O)C(O)=O)C(O)=O
InChI
1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m1/s1
InChI key
YYLQUHNPNCGKJQ-JCYAYHJZSA-N
Gene Information
human ... GLUL(2752)
mouse ... GLUL(14645)
General description
DL-threo-β-hydroxyaspartic acid (THA) is a glutamate uptake inhibitor.
Application
DL-threo-β-Hydroxyaspartic acid (THA) has been used to block glutamate transport in cannulated sprague dawley rat.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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A Hirata et al.
Brain research, 771(1), 37-44 (1998-02-12)
Excitotoxicity secondary to the loss of glutamate transporters (GluT) has been proposed as a possible pathogenetic mechanism for neuronal degeneration in amyotrophic lateral sclerosis. We therefore investigated whether prolonged in vivo pharmacologic inhibition of GluT would result in neuronal damage
Nina Bionda et al.
Amino acids, 42(1), 285-293 (2010-11-18)
A simple and practical general synthetic protocol towards orthogonally protected tHyAsp derivatives fully compatible with Fmoc solid-phase peptide synthetic methodology is reported. Our approach includes enantioresolution of commercially available D: ,L: -tHyAsp racemic mixture by co-crystallization with L: -Lys, followed
Ewa Nagańska et al.
Folia neuropathologica, 48(1), 35-44 (2010-04-13)
Erythropoietin (EPO) is a chemokine hormone that is widely distributed throughout the body including nervous system. For last years its role as cytokine involved in many physiological processes out of the bone marrow has been suggested. Moreover, it plays a
Tatiana Borisova et al.
Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology, 14(1), P81-P82 (2008-04-01)
Activity of high-affinity glutamate transporters was altered in brain nerve terminals under artificial gravity conditions. Blood platelets contain glutamate transporters and are able to uptake glutamate. The goal of the research was to analyze comparatively L-[14C]glutamate transport in neuronal and
Jixu Yu et al.
Brain research, 1257, 102-107 (2009-01-13)
Threohydroxyaspartate (THA)-induced glutamate excitotoxicity in organotypic culture of rat spinal cord is a well-known model of motor neuron degeneration. THA causes accumulation of synaptic glutamate and over stimulation of the postsynaptic receptor by inhibiting glutamate uptake. This model has also
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