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Merck

H7403

Anti-Histamine antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti Histamine Antibody, Histamine Antibody, Histamine Antibody - Anti-Histamine antibody produced in rabbit

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A propos de cet article

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
dot blot
immunohistochemistry
Species reactivity:
wide range
Citations:
17
Technique(s):
dot blot: 1:14,000 using histamine-BSA.
immunohistochemistry: 1:100 using 4% paraformaldehyde/4% carbodiimide-fixed or 4% paraformaldehyde-fixed sections of rat stomach
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Nom du produit

Anti-Histamine antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

wide range

technique(s)

dot blot: 1:14,000 using histamine-BSA.
immunohistochemistry: 1:100 using 4% paraformaldehyde/4% carbodiimide-fixed or 4% paraformaldehyde-fixed sections of rat stomach

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

Application

Anti-Histamine antibody produced in rabbit has been used:
  • in immunohistochemistry
  • to test immunohistochemical reactions of Pseudophoxinus antalyae digestive system tissues
  • in immunocytochemical assays
  • in immunofluorescence assays

Biochem/physiol Actions

Histamine, (2-(4-Imidazolyl)ethylamine) mediates a variety of physiological activities including inflammation, gastric acid secretion and smooth muscle contraction. It is also implicated in modulation of cell growth and differentiation, during embryogenesis, and tumor growth and in the suppression of mitogen-induced lymphocyte proliferation. In the central nervous system (CNS), histamine acts as a neurotransmitter/ neuromodulator of various brain activities.
The product specifically stains histamine-containing cells in paraformaldehyde/carbodiimide-fixed or paraformaldehyde-fixed, paraffin-embedded sections of rat stomach (endocrine cells and mast cells).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Histamine, (2-(4-Imidazolyl)ethylamine), is a widely distributed substance in peripheral tissues. Histamine is localized in mast cells, neuronal cells and neuroendocrine cells of the gastric tract. It is also expressed in lungs, kidney, in cerebrovascular endothelial cells and throughout the peripheral nervous system.

Immunogen

histamine conjugated to succinylated KLH

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide

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Classe de stockage

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Consulter la Bibliothèque de documents

Jonathon L McClain et al.
Biomolecules, 13(11) (2023-11-25)
Histamine is a neuromodulator that affects gut motility and visceral sensitivity through intrinsic and extrinsic neural pathways, yet the mechanisms regulating histamine availability in these pathways remain poorly understood. Here, we show that enteric glia contribute to histamine clearance in
The role of histamine H4 receptor in immune and inflammatory disorders
Zampeli E, et al.
British Journal of Pharmacology, 157, 24-24 (2009)
Drew Stenesen et al.
eLife, 4, e10972-e10972 (2015-12-15)
Synaptic transmission from Drosophila photoreceptors to lamina neurons requires recycling of histamine neurotransmitter. Synaptic histamine is cleared by uptake into glia and conversion into carcinine, which functions as transport metabolite. How carcinine is transported from glia to photoreceptor neurons remains
Jasmin Becker et al.
Frontiers in physiology, 10, 329-329 (2019-04-12)
The density of intestinal mast cells has been reported to increase during inflammatory bowel disease (IBD). As mast cell mediators are known to increase the permeability of epithelial tight junctions, we hypothesized that antigen responses in sensitized animals might be
Histamine mediates osteoclastic resorption only during the acute phase of bone loss in ovariectomized rats
Lesclous Ph, et al.
Experimental Physiology, 91(3), 561-570 (2006)

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