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Merck

H9039

Hémine

from bovine, ≥90%

Synonyme(s) :

Chloro(protoporphyrinato)fer(III), Chlorohémine, Chloroprotoporphyrine IX-fer(III), Chlorure de ferriprotoporphyrine IX, Hémine (chlorure)

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A propos de cet article

Formule empirique (notation de Hill) :
C34H32ClFeN4O4
Numéro CAS:
Poids moléculaire :
651.94
UNSPSC Code:
12352202
NACRES:
NA.61
PubChem Substance ID:
EC Number:
240-140-1
Beilstein/REAXYS Number:
5229914
MDL number:
Form:
powder
Assay:
≥90%
Biological source:
bovine
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InChI

1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;

SMILES string

Cc1c(CCC(O)=O)c2cc3c(CCC(O)=O)c(C)c4cc5nc(cc6c(C)c(C=C)c(cc1n2)n6[Fe](Cl)n34)c(C=C)c5C

InChI key

BTIJJDXEELBZFS-HXFTUNQESA-K

biological source

bovine

assay

≥90%

form

powder

technique(s)

toxicology assay: suitable

solubility

1.4 M NH4OH: soluble 25 mg/mL

storage temp.

2-8°C

Quality Level

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Application

L′hémine a été utilisée pour étudier la conjugaison, la caractérisation et la toxicité d′un conjugué lipophosphoglycane-acide polyacrylique pour la vaccination contre la leishmaniose.

General description

L′hème est une petite molécule qui se trouve dans la circulation sanguine des mammifères, soit libre, soit liée à l′hémoglobine. Elle sert de source secondaire de fer et contient un anneau porphyrine avec un ion Fe2+ appelé hémine.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Certificats d'analyse (COA)

Lot/Batch Number

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the solubility of Hemin, Product H9039?

    Hemin can be dissolved in basic solution.  A 25 mg/ml solution can be prepared in 1.4 M ammonium hydroxide with heating to 95°C for less than 5 minutes. Hemin is also expected to be soluble in a sodium hydroxide solution. Hemin has been reported to be soluble at 1 mM concentration in DMSO, per Tomlinson and Ferguson, Proceedings of the National Academy of Sciences, 97, 5156-5160 (2000).  A 0.25% hemin solution can also be prepared in 50% triethanolamine solution.

  4. How stable is Hemin, Product H9039, in solution?

    Sigma-Aldrich has not evaluated the solution stability of hemin solutions.  Also, we have not found any information on solution storage in the literature. We recommend that solutions be prepared fresh.

  5. What is the shelf life for Hemin, Product H9039?

    There is no shelf life date assigned to this product. The guarantee of quality is for one year from the time of shipment for bottles stored as recommended.

  6. What are some applications for Hemin, Product H9039?

    Hemin-agarose has reportedly been prepared for use in affinity chromatography of heme-binding proteins.  See Tsutsui, K., Affinity chromatography of heme-binding proteins: Synthesis of hemin-agarose. Meth. Enzymol. 123, 331, (1986). Sigma supplies a hemin agarose, product H6390. Hemin can also be used as a component in culture media for the cultivation of bacteria, such as Leishmania tarentolae.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Rodgoun Attarian et al.
mBio, 9(6) (2018-12-06)
The acquisition of iron and the maintenance of iron homeostasis are important aspects of virulence for the pathogenic fungus Cryptococcus neoformans In this study, we characterized the role of the monothiol glutaredoxin Grx4 in iron homeostasis and virulence in C.
Xiaoyu Shi et al.
Molecular microbiology, 114(3), 454-467 (2020-05-21)
Reticulon and REEP family of proteins stabilize the high curvature of endoplasmic reticulum (ER) tubules. Plasmodium berghei Yop1 (PbYop1) is a REEP5 homolog in Plasmodium. Here, we characterize its function using a gene-knockout (Pbyop1∆). Pbyop1∆ asexual stage parasites display abnormal
Post-embryonic development in Caenorhabditis elegans.
D L Riddle
International journal for parasitology, 17(1), 223-231 (1987-02-01)
Murat Topuzogullari et al.
Journal of biomedical science, 20, 35-35 (2013-06-05)
Research on the conjugates of synthetic polyelectrolytes with antigenic molecules, such as proteins, peptides, or carbohydrates, is an attractive area due to their highly immunogenic character in comparison to classical adjuvants. For example, polyacrylic acid (PAA) is a weak polyelectrolyte
Alistair Harrison et al.
Cell reports, 30(9), 2978-2988 (2020-03-05)
Bacteria adapt to dynamic changes in the host during chronic and recurrent infections. Bacterial microevolution is one type of adaptation that imparts a selective advantage. We hypothesize that recurrent episodes of disease promote microevolution through genetic mutations that modulate disease

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