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Merck

HT501320

Solution de formol, tamponnée à pH neutre (10 %)

histological tissue fixative

Synonyme(s) :

10% Neutral Buffered Formalin, 10% NBF, Formaldehyde, Methanal

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A propos de cet article

UNSPSC Code:
12171500
PubChem Substance ID:
24895889
NACRES:
NA.47
MDL number:
MFCD00003274

Principaux documents

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SMILES string

[O-]#[C+H2]

InChI

1S/CH2O/c1-2/h1H2

InChI key

WSFSSNUMVMOOMR-UHFFFAOYSA-N

biological source

synthetic

concentration

10% formalin (approx. 4% formaldehyde)

color

colorless

pH

6.90-7.10

density

1.080 g/cm3

application(s)

hematology
histology

storage temp.

room temp

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Catégories apparentées

Features and Benefits

  • 10% NBF is well-suited for large throughput laboratories.
  • It requires a relatively short period of fixation.
  • It can be used for the long-term storage of tissue.

Application

Il s'agit d'un fixateur histologique universel d'usage courant.
Formalin solution (neutral buffered, 10%) has been popularly used as a general-purpose histological fixative to fix tissue samples.
  • It effectively preserves the cellular and tissue morphology, maintaining the structural integrity required for microscopic examination.
  • It is used for routine histological staining, providing clear and detailed images of cellular structures.

Physical form

Solution tamponnée à pH neutre.

Biochem/physiol Actions

Formaldehyde is both a non-coagulant and an additive fixative. Formalin fixation is thought to form cross links between the aldehydes and the proteins, creating a gel, thus retaining cellular constituents in their in vivo relationship. Formaldehyde is known to penetrate tissue quickly, but the fixation process may take a long time to form the various cross links with tissue proteins.

General description

10% Neutral Buffered Formalin is the most used fixative throughout the world for light microscopy. Formalin solution is the commercially obtained solution containing 37% w/w (40% w/v) of formaldehyde in water. It requires a relatively short period of fixation. It is suitable for the long-term storage of tissue. Once properly fixed, the tissue should be able to withstand the subsequent stages of tissue processing or staining.

Packaging

Item is packaged in a 10L Cubitainer consisting of a plastic bladder inside of a cardboard box with an attached spigot.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Skin Sens. 1

wgk

WGK 3

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificats d'analyse (COA)

Lot/Batch Number
MKCX2455
MKCS7396
MKCS3833
MKCR9542
MKCR2423

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Consulter la Bibliothèque de documents

Histological and Histochemical Methods ? Theory and practice, 5th Edition
J. A. Kiernan
Histological and Histochemical Methods: Theory and Practice (2015)
Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.
Hassler M R, et al.
Nucleic Acids Research, 46(5), 2185-2196 (2018)
Quantifying size and number of adipocytes in adipose tissue.
Parlee S D, et al.
Methods in Enzymology, 537, 93-122 (2014)
Recapitulating spatiotemporal tumor heterogeneity in vitro through engineered breast cancer microtissues.
Mazio C, et al.
Acta Biomaterialia, 73, 236-249 (2018)
Ted M Hsu et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(48), 30744-30754 (2020-11-18)
Thirst is a highly potent drive that motivates organisms to seek out and consume balance-restoring stimuli. The detection of dehydration is well understood and involves signals of peripheral origin and the sampling of internal milieu by first order homeostatic neurons
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Product Information Sheet - HT501320

Product Information Sheet

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